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Exposure of Human Skin Models to KrCl Excimer Lamps: The Impact of Optical Filtering
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2021-02-05 , DOI: 10.1111/php.13383
Manuela Buonanno 1 , David Welch 1 , David J Brenner 1
Affiliation  

Far-UVC radiation is a promising technology that is potentially both effective at killing airborne microbes such as coronaviruses and influenza, and being minimally hazardous to the skin and eyes. Our previous studies on health risks from far-UVC have employed a krypton-chloride (KrCl) excimer lamp, emitting principally at 222 nm, supplemented with an optical filter to remove longer wavelength emissions inherent to these lamps. This study explores KrCl lamp health hazards by comparing filtered and unfiltered KrCl lamps using effective spectral irradiance calculations and experimental skin exposures. Analysis of effective irradiances showed a notable increase in allowable exposure when using a filter. Induction of DNA dimers (CPD and 6-4PP) was measured in human skin models exposed to a range of radiant exposures up to 500 mJ/cm2 . Compared to sham-exposed tissues, the unfiltered KrCl lamps induced a statistically significant increase in the yield of both DNA lesions at all the radiant exposures studied. Conversely, filtered KrCl lamps do not induce increased levels of dimers at the current daily TLV exposure limit for 222 nm (23 mJ/cm2 ). This work supports the use of filters for far-UVC KrCl excimer lamps when used to limit disease transmission in occupied locations.

中文翻译:

将人体皮肤模型暴露于 KrCl 准分子灯:光学过滤的影响

远紫外线辐射是一种很有前途的技术,它可能既能有效杀死空气中的微生物,如冠状病毒和流感,又对皮肤和眼睛的危害最小。我们之前对远 UVC 造成的健康风险的研究采用了氯化氪 (KrCl) 准分子灯,主要发射 222 nm,并辅以滤光片以消除这些灯固有的较长波长发射。本研究通过使用有效光谱辐照度计算和实验皮肤暴露比较过滤和未过滤的 KrCl 灯来探索 KrCl 灯的健康危害。对有效辐照度的分析表明,使用滤光片时可允许的曝光量显着增加。在暴露于高达 500 mJ/cm2 的辐射暴露范围的人体皮肤模型中测量了 DNA 二聚体(CPD 和 6-4PP)的诱导。与假暴露组织相比,未过滤的 KrCl 灯在所研究的所有辐​​射暴露下均导致两种 DNA 损伤的产量显着增加。相反,在 222 nm (23 mJ/cm2) 的当前每日 TLV 暴露限值下,过滤的 KrCl 灯不会导致二聚体水平升高。这项工作支持在用于限制疾病在有人居住的地方传播时,为远 UVC KrCl 准分子灯使用过滤器。
更新日期:2021-02-05
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