Front Cover Picture: Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2‐Aryl‐Substituted Pyrrolidines as Pharmaceutical Building Blocks (5/2021),Advanced Synthesis & Catalysis

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Front Cover Picture: Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2‐Aryl‐Substituted Pyrrolidines as Pharmaceutical Building Blocks (5/2021)
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-01-20 , DOI: 10.1002/adsc.202100049
Izabela Węglarz ₁ , Karol Michalak ₁ , Jacek Mlynarski ₁

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The front cover picture illustrates the application of Zn‐complex as a key catalyst for enantioselective hydrosilylation of cyclic imines. As the replacement of platinum‐group metals is currently an interesting challenge in catalysis, a promising alternative in asymmetric hydrosilylation, is to use environmentally benign and easily accessible chiral Zn‐based catalysts. I. Węglarz, K. Michalak and J. Mlynarski show that in situ generated zinc‐ProPhenol complex with silane affords pharmaceutically relevant enantioenriched 2‐aryl‐substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). Details can be found in the communication by Jacek Mlynarski and co‐workers (I. Węglarz, K. Michalak, J. Mlynarski, Adv. Synth. Catal. 2021, 363, 1317–1321; DOI: 10.1002/adsc.202001043).

中文翻译：

封面图片：环亚胺的锌催化不对称氢化硅烷化：手性2-芳基取代的吡咯烷类化合物的合成作为药物结构单元（5/2021）

所述前盖的画面示出了Zn的复合物中的应用程序作为一个键为环状亚胺对映选择性氢化硅烷化催化剂。由于铂族金属的取代目前在催化方面是一个有趣的挑战，因此，不对称氢化硅烷化的一种有前途的替代方法是使用对环境无害且易于获得的手性锌基催化剂。I.Węglarz，K。Michalak和J. Mlynarski表明，与硅烷原位生成的锌-ProPhenol复合物可提供高收率和出色的对映选择性（高达99％ee，可药用的对映体富集的2-芳基取代的吡咯烷））。细节可以在通过亚切克Mlynarski和同事的通信中找到（I.Węglarz，K. Michalak的，J. Mlynarski， 。。进阶Synth的CATAL。2021，363，1317年至1321年; DOI：10.1002 / adsc.202001043）。

更新日期：2021-03-03

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