For many years, it was postulated that the brain is the organ behind the barrier with an autonomous need for its maintenance. This view has been changed by the concept that the central nervous system is sensitive to the immune processes occurring in the periphery as well as to the infiltration of peripheral immune cells. However, how the immune system might contribute to the development of neurodegenerative diseases, such as Parkinson's disease (PD), remains unclear. PD is a chronic neurodegenerative disorder that affects motor and cognitive functions. Although the precise cause of PD is unknown, studies in both mice and human suggest that alterations in the innate immunity may play a critical role in modulating PD progression. Here, we review recent advancements in our understanding of inflammation and the innate immune mechanisms in PD pathology.

中文翻译：

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先天免疫和炎症在帕金森氏病中的作用

多年以来，人们一直认为大脑是屏障后面的器官，需要自动维护。中枢神经系统对周围发生的免疫过程以及周围免疫细胞的浸润敏感的概念已经改变了这种观点。但是，免疫系统如何促进神经退行性疾病（如帕金森氏病（PD））的发展尚不清楚。PD是一种慢性神经退行性疾病，会影响运动和认知功能。尽管PD的确切病因尚不清楚，但在小鼠和人类中的研究均表明，先天免疫力的改变可能在调节PD进程中起关键作用。这里，