Coughlin and colleagues [1] recently examined the association between hippocampal α-synuclein (SYN) and tau pathologies in 49 autopsy-confirmed cases of Lewy body diseases (LBD) - 30 with no/low Alzheimer disease (AD) co-pathology (LBD - AD) and 19 with moderate/high AD co-pathology (LBD + AD) aged at death 77.3 and 78.6 years, and disease duration 15.8 and 9.1 years, respectively, and 30 AD patients with a mean age of 74.4 years. 67% and 89%, respectively, were neocortical, 27% and 11%, respectively, limbic LBD stage, with only very few brainstem predominant forms [2]. LBD - AD and LBD + AD had similar severity and distribution of SYN pathology, subfield CA 2/3 being most severely affected, while CA1/subiculum and entorhinal cortex (ERC) were the most affected regions in AD. Tau pathology in both LBD - AD and LBD + AD was greatest in about two thirds, suggesting that tau burden in LBD was similar to the distribution of SYN in subfield CA 2/3, thus diverging from that in classical AD and contributing to memory dysfunction in LBD. β-Amyloid severity and distribution were similar between LBD + AD and AD.

中文翻译：

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路易体病和阿尔茨海默病海马亚区病理的不同模式

Coughlin 及其同事 [1] 最近检查了 49 例尸检证实的路易体病 (LBD) - 30 例无/低阿尔茨海默病 (AD) 共病 (LBD) 病例中海马 α-突触核蛋白 (SYN) 与 tau 病理之间的关联- AD) 和 19 名中度/高度 AD 共同病理 (LBD + AD)，死亡时年龄分别为 77.3 和 78.6 岁，病程分别为 15.8 和 9.1 年，30 名 AD 患者的平均年龄为 74.4 岁。67% 和 89% 分别为新皮质，27% 和 11% 分别为边缘系统 LBD 阶段，只有极少数脑干占优势的形式 [2]。LBD - AD 和 LBD + AD 具有相似的严重程度和 SYN 病理分布，亚区 CA 2/3 受影响最严重，而 CA1/下颌和内嗅皮层 (ERC) 是 AD 中受影响最严重的区域。LBD - AD 和 LBD + AD 中的 Tau 病理学在大约三分之二中最大，表明 LBD 中的 tau 负荷与子域 CA 2/3 中的 SYN 分布相似，因此与经典 AD 中的不同并导致记忆功能障碍在 LBD。β-淀粉样蛋白的严重程度和分布在 LBD + AD 和 AD 之间相似。