The NLRP3 inflammasome: Multiple activation pathways and its role in primary cells during ventricular remodeling,Journal of Cellular Physiology

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The NLRP3 inflammasome: Multiple activation pathways and its role in primary cells during ventricular remodeling
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-01-20 , DOI: 10.1002/jcp.30285
Zhipeng Yan _{1,

2} , Zhongwen Qi ₁ , Xiaoya Yang ₁ , Nan Ji ₁ , Yueyao Wang ₁ , Qi Shi ₁ , Meng Li ₁ , Junping Zhang ₁ , Yaping Zhu ₁

Affiliation

Inflammasomes are a group of multiprotein signaling complexes located in the cytoplasm. Several inflammasomes have been identified, including NLRP1, NLRP2, NLRP3, AIM2, and NLRC4. Among them, NLRP3 was investigated in most detail, and it was reported that it can be activated by many different stimuli. Increased NLRP3 protein expression and inflammasome assembly lead to caspase‐1 mediated maturation and release of IL‐1β, which triggers inflammation and pyroptosis. The activation of the NLRP3 inflammasome has been widely reported in studies of tumors and neurological diseases, but relatively few studies on the cardiovascular system. Ventricular remodeling (VR) is an important factor contributing to heart failure (HF) after myocardial infarction (MI). Consequently, delaying VR is of great significance for improving heart function. Studies have shown that the NLRP3 inflammasome plays an essential role in the process of VR. Here, we reviewed the latest studies on the activation pathway of the NLRP3 inflammasome, focusing on the effects of the NLRP3 inflammasome in primary cells during VR, and finally discuss future research directions in this field.

中文翻译：

NLRP3 炎性体：多种激活途径及其在心室重构过程中在原代细胞中的作用

炎性体是一组位于细胞质中的多蛋白信号复合物。已经鉴定了几种炎症小体，包括 NLRP1、NLRP2、NLRP3、AIM2 和 NLRC4。其中，对NLRP3 进行了最详细的研究，据报道它可以被许多不同的刺激激活。NLRP3 蛋白表达增加和炎症小体组装导致 caspase-1 介导的 IL-1β 成熟和释放，从而引发炎症和细胞焦亡。NLRP3 炎症小体的激活已在肿瘤和神经系统疾病的研究中得到广泛报道，但对心血管系统的研究相对较少。心室重构 (VR) 是导致心肌梗死 (MI) 后心力衰竭 (HF) 的重要因素。因此，延迟VR对改善心脏功能具有重要意义。研究表明，NLRP3炎症小体在VR过程中起着至关重要的作用。在此，我们回顾了 NLRP3 炎症小体激活途径的最新研究，重点关注 VR 过程中 NLRP3 炎症小体对原代细胞的影响，最后讨论了该领域的未来研究方向。

更新日期：2021-01-20

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