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Concomitant Polymorphism and Nucleation Control of DL‐Methionine Through Antisolvent Crystallization
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2021-01-20 , DOI: 10.1002/ceat.202000300 Manivel Suresh 1 , Karuppannan Srinivasan 1
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2021-01-20 , DOI: 10.1002/ceat.202000300 Manivel Suresh 1 , Karuppannan Srinivasan 1
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The concomitant polymorphism of the sulfur‐containing essential amino acid DL‐methionine was revealed, and α‐ and β‐polymorphic forms were separated from aqueous solution through antisolvent crystallization with ethanol as antisolvent. The addition of different volume fractions of ethanol into the mother solution reduces the solubility of DL‐methionine in double‐distilled water and in turn proportionately generates a range of supersaturation levels. This induces the nucleation of a stable β‐polymorph at low supersaturation levels, a mixture of α‐ and β‐ polymorphs at intermediate supersaturation levels, and a metastable α‐form at high supersaturation levels. Needle‐shaped α‐polymorphs and platy‐shaped β‐polymorphs were well distinguished through in‐situ optical microscopic analysis and their structural confirmation was done by X‐ray diffraction analysis.
中文翻译：
DL-蛋氨酸的多态性及其通过反溶剂结晶的成核控制
揭示了含硫必需氨基酸DL-蛋氨酸的伴随多态性，并通过以乙醇为反溶剂的反溶剂结晶从水溶液中分离出α-和β-多态性形式。在母液中添加不同体积分数的乙醇会降低DL蛋氨酸在双蒸馏水中的溶解度，并相应地产生一定范围的过饱和度。这会在低过饱和度下诱导出稳定的β-多晶型物的成核，在中度过饱和度下导致α-和β-多晶型物的混合物，以及亚稳态α在高过饱和度水平下形成。通过原位光学显微镜分析可以很好地区分针状α-多态性和板状β-多态性，并通过X射线衍射分析确定其结构。
更新日期：2021-03-19
中文翻译：
DL-蛋氨酸的多态性及其通过反溶剂结晶的成核控制
揭示了含硫必需氨基酸DL-蛋氨酸的伴随多态性，并通过以乙醇为反溶剂的反溶剂结晶从水溶液中分离出α-和β-多态性形式。在母液中添加不同体积分数的乙醇会降低DL蛋氨酸在双蒸馏水中的溶解度，并相应地产生一定范围的过饱和度。这会在低过饱和度下诱导出稳定的β-多晶型物的成核，在中度过饱和度下导致α-和β-多晶型物的混合物，以及亚稳态α在高过饱和度水平下形成。通过原位光学显微镜分析可以很好地区分针状α-多态性和板状β-多态性，并通过X射线衍射分析确定其结构。
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