A novel library of 1,2,4-oxadiazole linked 1,2,4-thiadiazole-pyrimidines (10a-j) were designed and synthesized. All compounds were characterized by FTIR, NMR and high resolution Mass analysis. Further, these compounds were screened for their anticancer activity against a panel of human cancer cell lines such as MCF-7 (human breast cancer), A-549 (human non -small cell lung cancer), Colo-205 (human adenocarcinoma colon cancer) and A2780 (human ovarian cancer) by employing MTT assay. The clinical drug (etoposide) used as positive control. Among all synthesized compounds, five compounds 10b, 10c, 10d, 10i and 10j were possessed more promising anticancer activity on all cell lines.

设计并合成了一个新的1,2,4-恶二唑连接的1,2,4-噻二唑-嘧啶（10a-j）库。所有化合物均通过FTIR，NMR和高分辨率质谱分析进行了表征。此外，筛选了这些化合物对一组人类癌细胞系例如MCF-7（人类乳腺癌），A-549（人类非小细胞肺癌），Colo-205（人类腺癌结肠癌）的抗癌活性。 ）和A2780（人类卵巢癌）。临床药物（依托泊苷）用作阳性对照。在所有合成的化合物中，五个化合物10b，10c，10d，10i和10j在所有细胞系中均具有更有希望的抗癌活性。