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Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients
Saudi Journal of Biological Sciences Pub Date : 2021-01-20 , DOI: 10.1016/j.sjbs.2021.01.013
Tongfei Wang , Wei Li , Haitao Li , Weina Li

Non-small cell lung cancer (NSCLC) is the main reason of cancer linked mortality and around 80% of cases diagnosed in advanced stage. Therefore current study designed to evaluate the deregulation of miRNA-194 and miRNA-192 in different body fluid of Non small cell lung cancer participants. Present study recruited newly diagnosed histopathologically confirmed. It was observed that the 40% NSCLC participants showed elevated miR-194 expression and 60% NSCLC participants showed reduced miR-194 expression in serum sample while in Bronchial wash, only 20% NSCLC participants showed elevated miR-194 expression while 80% showed reduced miR-194 expression (p = 0.003). It was found that the 54% NSCLC participants showed elevated miR-192 expression and 55% NSCLC participants showed reduced miR-192 expression in serum sample while In Bronchial wash sample, only 25% NSCLC participants showed high miR-192 expression while 75% showed low miR-192 expression (P = 0.0004). Expression of miR-194 was significantly associated with TNM stages (p < 0.0001, p < 0.0001), distant organ metastases (p < 0.0001, p < 0.0001), pathological grade (p = 0.0009, p = 0.0005) among serum sample and bronchial wash sample. Same observation was found with expression of miR-192 and it was significantly associated with TNM stages (p < 0.0001, p < 0.0001), distant organ metastases (p < 0.0001, p < 0.0001), pathological grade (p = 0.006, p = 0.001) among serum sample and bronchial wash sample. It was observed that the NSCLC participants who had high serum based miR-194 expression showed 22 months of overall median survival while low expression of serum based miR-194 expression showed 18 months of overall median survival. Present study suggests that decreased expression of miR-194 and miR-192 was significantly associated with different clinical features of NSCLC cases. However, significantly higher number of NSCLC cases showed low expression of miR-194 and miR-192 in bronchial lavage sample. Decreased poor overall survival was found to be associated with bronchial wash sample with respect to low miR-194 and miR-192 expression while NSCLC participants showed better overall survival with high miR-194 and miR-192 expression. This suggested decreased expression of miR-192 and miR-194 expression could be the potential prognostic marker among NSCLC participants.



中文翻译:

肺腺癌患者外泌体miR-192和miR-194表达异常

非小细胞肺癌(NSCLC)是与癌症相关的死亡率的主要原因,约80%的晚期病例被诊断出来。因此,当前的研究旨在评估非小细胞肺癌参与者不同体液中miRNA-194和miRNA-192的失调。本研究募集的新诊断经组织病理学证实。观察到40%的NSCLC参与者的血清样品中miR-194表达升高,而60%的NSCLC参与者的血清样品中miR-194表达降低,而在支气管冲洗液中,只有20%的NSCLC参与者的miR-194表达升高,而80%的患者的miR-194表达降低。 miR-194表达(p = 0.003)。发现在血清样本中有54%的NSCLC参与者显示了较高的miR-192表达,而55%的NSCLC参与者显示了降低的miR-192表达,而在支气管清洗样本中,只有25%的NSCLC参与者显示高miR-192表达,而75%则显示低miR-192表达(P = 0.0004)。miR-194的表达与TNM分期(p <0.0001,p <0.0001),远处器官转移(p <0.0001,p <0.0001),病理学分级(p = 0.0009,p = 0.0005)显着相关。洗涤样品。在miR-192的表达中发现了相同的观察结果,并且与TNM分期(p <0.0001,p <0.0001),远处器官转移(p <0.0001,p <0.0001),病理分级(p = 0.006,p =血清样品和支气管清洗样品中的0.001)。观察到具有高的基于血清的miR-194表达的NSCLC参与者显示出22个月的总体中位生存期,而低的基于血清的miR-194的表达表明18个月的总体中位生存期。目前的研究表明,miR-194和miR-192的表达下降与NSCLC病例的不同临床特征显着相关。但是,在支气管灌洗液样本中,明显多于NSCLC的病例显示出miR-194和miR-192的低表达。对于低miR-194和miR-192表达,发现不良的总生存率降低与支气管洗液样本有关,而NSCLC参与者在高miR-194和miR-192表达情况下表现出更好的总生存率。目前的研究表明,miR-194和miR-192的表达下降与NSCLC病例的不同临床特征显着相关。然而,明显更多的NSCLC病例在支气管灌洗液样本中显示出miR-194和miR-192的低表达。对于低miR-194和miR-192表达,发现不良的总生存率降低与支气管洗液样本有关,而NSCLC参与者在高miR-194和miR-192表达情况下表现出更好的总生存率。目前的研究表明,miR-194和miR-192的表达下降与NSCLC病例的不同临床特征显着相关。然而,明显更多的NSCLC病例在支气管灌洗液样本中显示出miR-194和miR-192的低表达。对于低miR-194和miR-192表达,发现不良的总生存率降低与支气管洗液样本有关,而NSCLC参与者在高miR-194和miR-192表达情况下表现出更好的总生存率。 这表明miR-192和miR-194表达的降低可能是NSCLC参与者中潜在的预后标志物。

更新日期:2021-03-04
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