The formulation of drug considering the body fluid ingredients is important and therefore study of the interaction of drug-surfactant in fluid ingredients medium is very significant. Herein, we applied a conductivity technique to insight the interaction of cephradine monohydrate (CDM) drug with cationic surfactant- cetyltrimethylammonium bromide (CTAB) and anionic surfactant- sodium dodecyl sulfate (SDS)) while UV–visible spectroscopic was employed to observe the interaction of CDM with non-ionic surfactant, triton X-100 (TX-100). The experimental temperature ranges were 303.15–328.15 K and 293.15–323.15 K for CDM + CTAB and CDM + SDS systems respectively in the case of the conductivity study whereas for UV–visible spectroscopic study the temperature was kept in the range of 298.15–318.15 K. The values of critical micelle concentration (CMC) of CDM + CTAB and CDM + SDS systems were analyzed from their conductivity data in H₂O and aqueous NaCl solution. The CMC values were found to be lower for CDM + CTAB and CDM + SDS systems as compared to corresponding pure surfactants. The CMC values were found to be influenced by the variation of experimental temperature. The micellization of CDM + CTAB and CDM + SDS systems was favored in the presence of NaCl and augmentation of NaCl concentration generates a more favorable condition for micellization of studied systems. The values of counter ion dissociation (α) were found to be temperature and additives dependent. The free energy of micellization (∆G_m^o) indicates that micellization of CDM + CTAB and CDM + SDS systems was thermodynamically spontaneous which further augmented with the boost of NaCl concentration. The computed enthalpy and entropy values exhibit a linear relationship in all cases for CDM + CTAB and CDM + SDS systems. The binding constant (K_b) between CDM and TX-100 was found to be increased with the augmentation of CDM concentration and exhibit U-like variation as temperature increases. The binding between CDM and TX-100 was also thermodynamically spontaneous.

考虑到体液成分的药物配方很重要，因此研究药物表面活性剂在液体成分介质中的相互作用非常重要。在本文中，我们采用电导率技术来了解头孢拉定一水合物（CDM）药物与阳离子表面活性剂-十六烷基三甲基溴化铵（CTAB）和阴离子表面活性剂-十二烷基硫酸钠（SDS））的相互作用，同时采用紫外可见光谱法观察具有非离子表面活性剂Triton X-100（TX-100）的CDM。对于电导率研究，CDM + CTAB和CDM + SDS系统的实验温度范围分别为303.15–328.15 K和293.15–323.15 K，而对于UV-可见光谱研究，温度保持在298.15–318.15 K临界胶束浓度的值（从在H ₂ O和NaCl水溶液中的电导率数据分析了CDM + CTAB和CDM + SDS系统的CMC）。与相应的纯表面活性剂相比，发现CDM + CTAB和CDM + SDS系统的CMC值较低。的CMC发现值，以通过实验温度的变化的影响。在存在NaCl的情况下，CDM + CTAB和CDM + SDS系统的胶束化是有利的，NaCl浓度的增加为研究系统的胶束化提供了更有利的条件。发现抗衡离子离解值（α）与温度和添加剂有关。胶束化的自由能（∆ G _m ^o）表明CDM + CTAB和CDM + SDS系统的胶束化是热力学自发的，随着NaCl浓度的增加而进一步增加。对于CDM + CTAB和CDM + SDS系统，在所有情况下，计算出的焓和熵值均呈线性关系。发现CDM和TX-100之间的结合常数（K _b）随着CDM浓度的增加而增加，并且随着温度升高而呈现出U样变化。CDM和TX-100之间的结合也是热力学自发的。