Immunorelevant genes are among the most probable modulators of coronavirus disease 2019 (COVID-19) progression and prognosis. However, in the few months of the pandemic, data generated on host genetics has been scarce. The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. Additionally, HLA-B correlations suggest that differences in allele affinities to SARS-CoV-2 peptides are also associated with DDR. These results may provide rationale for future host genetic marker surveys on COVID-19.

免疫相关基因是 2019 年冠状病毒病 (COVID-19) 进展和预后最可能的调节因子之一。然而，在大流行的几个月里，有关宿主遗传学的数据很少。本研究从 AlleleFrequencyNetDatabase 和 Ensembl 这两个公开数据库中检索了与 COVID-19 细胞因子风暴相关的细胞因子中的 HLA-B 等位基因、KIR 基因和功能性单核苷酸多态性 (SNP) 数据集，并将这些频率数据与各国的病死率 (CFR) 和每日死亡率 (DDR)。观察到 8 个HLA-B等位基因和 3 个细胞因子基因（IL6、IL10和IL12B）多态性的相关性，并且主要与 DDR 相关。此外，HLA-B相关性表明 SARS-CoV-2 肽等位基因亲和力的差异也与 DDR 相关。这些结果可能为未来针对 COVID-19 的宿主遗传标记调查提供依据。