A new polysaccharide from fruits of Schisandra chinensis (SCPP22) with a molecular weight of 143 ± 0.13 KDa was mainly made up of glucose and galactose. The possible structure of SCPP22 was showed that its main chain was composed of 1,4-α-d-Glup and branch was stretched from O-6 position of 1,4-β-d-Glup. Branches consisted of T-α-d-Galp. Further, SCPP22 could reverse PCB126-induced immunosuppression, significantly enhance body weight and immune organ indices. It also significantly ameliorated oxidative injury to immune organ induced by PCB126, as shown by evaluation of SOD activities, as well as MDA levels in spleen and thymus. SCPP22 strongly stimulated cytokines production by up-regulating mRNA expression of TNF-α, INF-γ and IL-2. Mechanism investigation revealed that recovery effects of SCPP22 in immunosuppression induced by PCB126 are mainly through regulating apoptosis-related proteins expression. Schisandra polysaccharides might be applied in functional food as nutritional intervention ingredient.

五味子果实中的一种新多糖（SCPP22）的分子量为143±0.13 KDa，主要由葡萄糖和半乳糖组成。SCPP22可能的结构表明，它的主链是由1,4-α-的d -Glu p和分支从1,4-β-的O-6位置拉伸d -Glu p。分支由T-α- d -Gal p组成。此外，SCPP22可以逆转PCB126诱导的免疫抑制，显着增加体重和免疫器官指数。通过评估SOD活性以及脾脏和胸腺中的MDA水平，可以显着改善PCB126对免疫器官的氧化损伤。SCPP22通过上调TNF-α，INF-γ和IL-2的mRNA表达来强烈刺激细胞因子的产生。机制研究表明，SCPP22在PCB126诱导的免疫抑制中的恢复作用主要是通过调控凋亡相关蛋白的表达。五味子多糖可作为营养干预成分用于功能性食品。