Prostate cancer (PCa) is the second most commonly diagnosed and third lethal cause of death from cancer in men worldwide. Despite the availability of vast treatment procedures, still the high occurrence of invasion and metastasis of PCa are reported in cancer patients. The WASP (Wiskott-Aldrich syndrome protein) and WAVE (WASP family verprolin homologous protein) family of proteins are actin cytoskeleton regulatory proteins, reported to enhance cancer cell invasion and migration in prostate cancer. Hence, this review sheds light on the studies that explored the potential role of WASP and WAVE family of proteins in invasion and metastasis of prostate cancer. The research articles explored for the completion of this review were mostly from PubMed and Google Scholar by using the appropriate keywords for indexing. The conserved function of WASP and WAVE protein family is to receive the upstream signals from the Rho GTPase family and transmit them to activate the Arp2/3 complex that leads to rapid actin polymerization at leading edge of cells, which is crucial for PCa metastasis. Therefore, targeting these proteins could reflect a very interesting therapeutic opportunity to combat prostate cancer.

中文翻译：

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WASP和WAVE家族蛋白在前列腺癌进展中的作用机制

前列腺癌 (PCa) 是全球男性癌症死亡的第二大常见原因和第三大致死原因。尽管有大量的治疗程序可供使用，但仍有报道称癌症患者中 PCa 的侵袭和转移发生率很高。WASP（Wiskott-Aldrich 综合征蛋白）和 WAVE（WASP 家族 verprolin 同源蛋白）蛋白家族是肌动蛋白细胞骨架调节蛋白，据报道可增强前列腺癌中的癌细胞侵袭和迁移。因此，本综述阐明了探索 WASP 和 WAVE 蛋白家族在前列腺癌侵袭和转移中的潜在作用的研究。为完成本综述而探索的研究文章大多来自 PubMed 和 Google Scholar，使用适当的关键字进行索引。WASP 和 WAVE 蛋白家族的保守功能是接收来自 Rho GTPase 家族的上游信号，并将其传输以激活 Arp2/3 复合物，从而导致细胞前沿快速肌动蛋白聚合，这对 PCa 转移至关重要。因此，靶向这些蛋白质可以反映一个非常有趣的治疗前列腺癌的机会。