There are several promises on the market related to the consumption of dietary supplements such as health benefits, improvements in body performance, combating aging and weight loss. One of the risks to consumers of dietary supplements is related to adulteration by substances that can cause adverse health reactions. The aim of this study was to develop a qualitative screening method for the detection of substances with pharmacological properties: stimulants, anorectic and diuretics in dietary supplement samples. A spectral database, using the following analytical techniques: molecular absorption spectroscopy in the UV and Fourier transform infrared (FTIR) regions, nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (MS), was created to compare the chromatograms of the samples and the standards searched. Two columns were tested, Ace® and Phenomenex®, and the result was compared for the screening methods developed separately for each column. The Phenomenex® column was chosen for the sample analysis using HPLC–DAD.

中文翻译：

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鉴别膳食补充剂中 17 种掺假物的快速筛查方法

市场上有一些与膳食补充剂消费相关的承诺，例如健康益处、改善身体机能、抗衰老和减肥。膳食补充剂消费者面临的风险之一与可能导致不良健康反应的物质掺假有关。本研究的目的是开发一种用于检测具有药理特性的物质的定性筛选方法：膳食补充剂样品中的兴奋剂、食欲减退剂和利尿剂。使用以下分析技术创建了一个光谱数据库：UV 和傅里叶变换红外 (FTIR) 区域的分子吸收光谱、核磁共振 (NMR) 光谱和高分辨率质谱 (MS)，以比较这些样品的色谱图。样品和标准检索。测试了两种色谱柱，Ace® 和 Phenomenex®，并将结果与​​为每根色谱柱单独开发的筛选方法进行比较。选择 Phenomenex® 色谱柱用于使用 HPLC-DAD 的样品分析。