This study was aimed to examine the effects of caffeic acid phenethyl ester (CAPE) on endothelial dysfunction in rats with exercise-induced oxidative stress. Tests were performed on male (n=32) young adult Sprague-Dawley rats (12 weeks of age). The experimental animals were divided into four groups in equal numbers. Group 1: General control group; Group 2: Swimming control group. Group 3: CAPE supplemented general control group. Group 4: CAPE supplemented swimming group. Furthermore, animals used in the experiment were made to do exhaustion practice toward the end of the examination. Plasma and liver tissue asymmetric dimethylarginine (ADMA) concentrations were not significantly (p0.05) increased in rats with acute swimming exercise compared to controls. Blood and liver cytokines levels were expanded in comparison to control group and CAPE groups (p0.05). Total antioxidant status (TAS) levels in acute swimming exercise groups reduced compared to the control group. Besides, total oxidant status (TOS) levels were considerably elevated compared to the control and CAPE groups. In this study, acute swimming exercise induced that oxidative stress could cause early onset of endothelial damage. Besides, CAPE can demonstrate protective effects on endothelial damage, inflammation and oxidative stress axis.

中文翻译：

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力竭运动引起的咖啡酸苯乙基酯和氧化应激对内皮损伤的影响。

这项研究旨在探讨咖啡酸苯乙酯（CAPE）对运动诱发的氧化应激大鼠内皮功能障碍的影响。在雄性（n = 32）年轻的成年Sprague-Dawley大鼠（12周龄）上进行了测试。将实验动物分成相等数量的四组。第一组：一般对照组；第2组：游泳对照组。第3组：CAPE补充的一般对照组。第4组：CAPE补充游泳组。此外，使实验中使用的动物在检查快要结束时进行精疲力尽练习。与对照组相比，急性游泳运动大鼠的血浆和肝组织不对称二甲基精氨酸（ADMA）浓度没有显着增加（p0.05）。与对照组和CAPE组相比，血液和肝细胞因子水平升高（p0.05）。与对照组相比，急性游泳运动组的总抗氧化剂状态（TAS）水平降低。此外，与对照组和CAPE组相比，总氧化剂状态（TOS）水平显着提高。在这项研究中，急性游泳运动诱导氧化应激可能引起内皮损伤的早期发作。此外，CAPE可以显示对内皮损伤，炎症和氧化应激轴的保护作用。急性游泳运动导致氧化应激可能引起内皮损伤的早期发作。此外，CAPE可以显示对内皮损伤，炎症和氧化应激轴的保护作用。急性游泳运动导致氧化应激可能引起内皮损伤的早期发作。此外，CAPE可以显示对内皮损伤，炎症和氧化应激轴的保护作用。