Several antiretrovirals including dolutegravir, rilpivirine and cobicistat inhibit tubular creatinine secretion, leading to benign increases in serum creatinine and reductions in estimated glomerular filtration rate (eGFR). This commentary discusses the magnitude and pattern of eGFR decline, whether this can be overcome by applying a standardized correction factor (as reported by Brunet et al. in Antiviral Therapy), the value of serial eGFR measures to detect rapid eGFR decline, and the potential utility of cystatin C as an alternative biomarker of kidney function.

中文翻译：

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校正 eGFR 以了解 ART 对肾小管肌酐分泌的影响：一种尺寸是否适合所有人？

包括 dolutegravir、rilpivirine 和 cobicistat 在内的几种抗逆转录病毒药物抑制肾小管肌酐分泌，导致血清肌酐良性增加和估计肾小球滤过率 (eGFR) 降低。本评论讨论了 eGFR 下降的幅度和模式，是否可以通过应用标准化校正因子（如 Brunet 等人在 Antiviral Therapy 中报道）来克服这一点，连续 eGFR 测量值检测快速 eGFR 下降的价值，以及潜在的胱抑素 C 作为肾功能的替代生物标志物的效用。