Fluorescent polymers via post-polymerization modification of Biginelli-type polymers for cellular protection against UV damage,Polymer Chemistry

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Fluorescent polymers via post-polymerization modification of Biginelli-type polymers for cellular protection against UV damage
Polymer Chemistry ( IF 4.1 ) Pub Date : 2021-1-14 , DOI: 10.1039/d0py00503g
Tengfei Mao _{1,

2,

3,

4,

5} , Xianzhe He _{3,

6,

7,

8,

9} , Guoqiang Liu _{3,

6,

7,

8,

9} , Yen Wei _{3,

6,

7,

8,

9} , Yanzi Gou _{3,

4,

5,

10} , Xingui Zhou _{3,

4,

5,

10} , Lei Tao _{3,

6,

7,

8,

9}

Affiliation

The development of biofriendly UV-protective materials is important because current UV-screening inorganic nanoparticles and organic small molecules have potential safety risks. In this research, new polymers with dramatic UV-protective capabilities have been effectively prepared through post-polymerization modification (PPM) of a Biginelli-type copolymer. The resulting polymers are fluorescent because of the heterocyclic structures generated by PPM; thus, the endocytosis of these polymers could be easily detected. The conjugated polymers obtained by the PPM method present low cytotoxicity and are superior to the unconjugated original Biginelli-type polymer in preventing UV-induced DNA damage and cell necrosis. This work demonstrates that the combination of the Biginelli reaction with the PPM method is a viable strategy for developing biocompatible UV-protective polymers for practical applications.

中文翻译：

通过Biginelli型聚合物的后聚合改性制成的荧光聚合物，用于细胞保护免受紫外线伤害

生物友好型紫外线防护材料的开发非常重要，因为目前的紫外线屏蔽无机纳米颗粒和有机小分子具有潜在的安全隐患。在这项研究中，已经通过Biginelli型共聚物的后聚合改性（PPM）有效地制备了具有显着紫外线防护功能的新型聚合物。由于PPM产生的杂环结构，所得的聚合物是发荧光的。因此，可以容易地检测到这些聚合物的内吞作用。通过PPM方法获得的共轭聚合物具有较低的细胞毒性，在防止紫外线引起的DNA损伤和细胞坏死方面优于未共轭的原始Biginelli型聚合物。

更新日期：2021-01-19

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