Rh(I)- and Rh(II)-catalyzed C–H alkylation of benzylamines with alkenes and its application in flow chemistry,Chemical Science

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Rh(I)- and Rh(II)-catalyzed C–H alkylation of benzylamines with alkenes and its application in flow chemistry
Chemical Science ( IF 7.6 ) Pub Date : 2021-1-4 , DOI: 10.1039/d0sc05813k
Amrita Das ₁ , Naoto Chatani ₁

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The Rh-catalyzed C–H alkylation of benzylamines with alkenes using a picolinamide derivative as a directing group is reported. Both Rh(I) and Rh(II) complexes can be used as active catalysts for this transformation. In addition, a flow set up was designed to successfully mimic this process under flow conditions. Several examples are presented under flow conditions and it was confirmed that a flow process is advantageous over a batch process. Deuterium labelling experiments were performed to elucidate the mechanism of the reaction, and the results indicated a possible carbene mechanism for this C–H alkylation process.

中文翻译：

Rh（I）和Rh（II）催化苄胺与烯烃的C–H烷基化及其在流动化学中的应用

据报道，使用吡啶甲酰胺衍生物作为直接基团，Rh催化了苄基胺与烯烃的C–H烷基化。Rh（I）和Rh（II）配合物均可用作该转化的活性催化剂。此外，设计了一种流量设置以成功模拟流量条件下的此过程。在流动条件下给出了几个例子，并且证实了流动过程优于分批过程。进行氘标记实验以阐明反应机理，结果表明该C–H烷基化过程可能存在卡宾机理。

更新日期：2021-01-19

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