Uropathogenic Escherichia coli (UPEC) causes urinary tract infections that can result in sepsis. The haemostatic system is protective in the pyelonephritis stage of ascending UPEC infection, but the role of the haemostatic system has not been investigated during sepsis. Here we utilize a zebrafish-UPEC systemic infection model to visualize infection-induced coagulation and examine the effects of commonly prescribed anti-haemostatic medications on the infection severity. Treatment of systemically infected zebrafish with warfarin, aspirin, or ticagrelor reduced host survival, while stabilization of clots with aminocaproic acid increased host survival. Anti-haemostatic drug treatment increased UPEC burden. Our findings provide evidence that commonly prescribed anti-haemostatic medications may worsen the outcome of severe UPEC infection.

中文翻译：

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常见的抗止血药物会增加尿路致病性大肠杆菌全身感染的严重程度

尿路致病性大肠杆菌(UPEC) 会导致尿路感染，从而导致败血症。止血系统在上行 UPEC 感染的肾盂肾炎阶段具有保护作用，但在败血症期间尚未研究止血系统的作用。在这里，我们利用斑马鱼-UPEC 全身感染模型来可视化感染诱导的凝血，并检查常用抗止血药物对感染严重程度的影响。用华法林、阿司匹林或替格瑞洛治疗全身感染的斑马鱼可降低宿主存活率，而用氨基己酸稳定凝块可增加宿主存活率。抗止血药物治疗增加了 UPEC 负担。我们的研究结果提供证据表明，常用的抗止血药物可能会使严重 UPEC 感染的结果恶化。