Continuous monitoring of in vivo pulsatile blood flow and pulse wave velocity (PWV) is important for clinical applications. These parameters are correlated with physiological parameters, such as blood pressure and elasticity of blood vessels. A multimode fiber diffuse speckle contrast analysis (MMF-DSCA) system was developed for fast measurement of in vivo pulsatile blood flow and pulse wave velocity. With MMF and CCD sensor, the diffuse speckle could be captured and processed with higher temporal resolution of 3 ms. We also induced for the first time an MMF-DSCA for evaluation of PWV, which allows estimation of the blood pressure continuously. To validate its performance, both phantom and in vivo experiments were conducted. The results demonstrate that MMF-DSCA could achieve fast pulsatile blood flow measurement with detailed information of the pulse wave profile and velocity. Taking the advantages of being simple and cost-effective, the flexible system can be easily adapted for continuous monitoring of vital biosigns, such as heart rate, pulse wave, and blood pressure.

持续监控 体内搏动性血流和脉搏波速度（PWV）对于临床应用很重要。这些参数与诸如血压和血管弹性的生理参数相关。开发了一种多模光纤散斑对比分析（MMF-DSCA）系统，用于快速测量体内搏动性血流和脉搏波速度。使用MMF和CCD传感器，可以捕获散斑，并以3 ms的更高时间分辨率进行处理。我们还首次引入了用于评估PWV的MMF-DSCA，从而可以连续估算血压。为了验证其性能，幻影和体内进行了实验。结果表明，MMF-DSCA可以通过脉搏波轮廓和速度的详细信息实现快速脉搏血流测量。利用简单且经济高效的优势，该灵活系统可以轻松地用于连续监测重要的生物信号，例如心率，脉搏波和血压。