The orally disintegrating tablet (ODT) has shown vast potential as an alternative oral dosage form to conventional tablets wherein they can disintegrate rapidly (≤30 s) upon contact with saliva fluid and should have an acceptable mouthfeel as long as their weight doesn’t exceed 500 mg. However, owing to the bitterness of several active ingredients, there is a need to find a suitable alternative to ODTs that maintains their features and can be taste-masked more simply and inexpensively. Therefore, electrospun nanofibers and solvent-cast oral dispersible films (ODFs) are used in this study as potential OD formulations for prednisolone sodium phosphate (PSP) that is commercially available as ODTs. The encapsulation efficiency (EE%) of the ODFs was higher (≈100%) compared to the nanofibers (≈87%), while the disintegration time was considerably faster for the electrospun nanofibers (≈30 s) than the solvent-cast ODFs (≈700 s). Hence, accelerated release rate of PSP from the nanofibers was obtained, due to their higher surface area and characteristic surface morphology that permitted higher wettability and thus, faster erosion. Taste-assessment study using the electronic-tongue quantified the bitterness threshold of the drug and its aversiveness concentration (2.79 mM). Therefore, a taste-masking strategy would be useful when further formulating PSP as an OD formulation.

中文翻译：

---

泼尼松龙磷酸钠口腔崩解片的潜在替代剂

口腔崩解片（ODT）作为常规片剂的替代口服剂型已显示出巨大的潜力，其中它们与唾液接触后可迅速崩解（≤30s），并且只要其重量不超过口感，其口感就可以接受500毫克 然而，由于几种活性成分的苦味，需要找到一种适合的ODT替代品，其保持其特征并且可以更简单且廉价地掩盖味道。因此，在这项研究中，静电纺丝纳米纤维和溶剂浇铸的口腔可分散薄膜（ODF）被用作磷酸泼尼松龙磷酸钠（PSP）的潜在OD制剂，可作为ODT商购获得。与纳米纤维（≈87％）相比，ODF的封装效率（EE％）更高（≈100％），而电纺纳米纤维的崩解时间（≈30s）比溶剂浇铸的ODF（≈700s）要快得多。因此，由于它们的更大的表面积和特征性的表面形态，使得从纳米纤维中获得了PSP的加速释放速率，从而允许了更高的润湿性，从而实现了更快的侵蚀。使用电子舌进行的味觉评估研究量化了该药物的苦味阈值及其厌恶浓度（2.79 mM）。因此，当进一步将PSP配制为OD制剂时，掩味策略将很有用。使用电子舌进行的味觉评估研究量化了该药物的苦味阈值及其厌恶浓度（2.79 mM）。因此，当进一步将PSP配制为OD制剂时，掩味策略将很有用。使用电子舌进行的味觉评估研究量化了该药物的苦味阈值及其厌恶浓度（2.79 mM）。因此，当进一步将PSP配制为OD制剂时，掩味策略将很有用。