Pseudomonas mendocina is an environmental bacterium, rarely isolated in clinical specimens, although it has been described as producing endocarditis and sepsis. Little is known about its genome. Whole genome sequencing can be used to learn about the phylogeny, evolution, or pathogenicity of these isolates. Thus, the aim of this study was to analyze the resistome, virulome, and phylogenetic relationship of two P. mendocina strains, Ps542 and Ps799, isolated from a healthy Anas platyrhynchos fecal sample and a lettuce, respectively. Among all of the small number of P. mendocina genomes available in the National Center for Biotechnology Information (NCBI) repository, both strains were placed within one of two well-defined phylogenetic clusters. Both P. mendocina strains lacked antimicrobial resistance genes, but the Ps799 genome showed a MOBP3 family relaxase. Nevertheless, this study revealed that P. mendocina possesses an important number of virulence factors, including a leukotoxin, flagella, pili, and the Type 2 and Type 6 Secretion Systems, that could be responsible for their pathogenesis. More phenotypical and in vivo studies are needed to deepen the association with human infections and the potential P. mendocina pathogenicity.

中文翻译：

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环境 Pseudomonas mendocina 菌株的全基因组分析：毒力机制和系统发育

Pseudomonas mendocina 是一种环境细菌，很少在临床标本中分离出来，尽管它已被描述为引起心内膜炎和败血症。人们对其基因组知之甚少。全基因组测序可用于了解这些分离株的系统发育、进化或致病性。因此，本研究的目的是分析两种 P. mendocina 菌株 Ps542 和 Ps799 的抗性组、病毒组和系统发育关系，它们分别从健康的鸭嘴兽粪便样本和生菜中分离出来。在国家生物技术信息中心 (NCBI) 存储库中可用的所有少量 P. mendocina 基因组中，两种菌株都被置于两个明确定义的系统发育簇之一中。两种 P. mendocina 菌株都缺乏抗菌素抗性基因，但 Ps799 基因组显示出 MOBP3 家族松弛酶。尽管如此，这项研究表明，门多西纳假单胞菌拥有许多重要的毒力因子，包括白细胞毒素、鞭毛、菌毛以及 2 型和 6 型分泌系统，它们可能是其发病机制的原因。需要更多的表型和体内研究来加深与人类感染和潜在 P. mendocina 致病性的关联。