After the recent announcement of COVID-19 vaccine efficacy in clinical trials by several manufacturers for protection against severe disease, a comprehensive post-efficacy strategy for the next steps to ensure vaccination of the global population is now required. These considerations should include how to manufacture billions of doses of high-quality vaccines, support for vaccine purchase, coordination of supply, the equitable distribution of vaccines and the logistics of global vaccine delivery, all of which are a prelude to a massive vaccination campaign targeting people of all ages. Furthermore, additional scientific questions about the vaccines remain that should be answered to improve vaccine efficacy, including questions regarding the optimization of vaccination regimens, booster doses, the correlates of protection, vaccine effectiveness, safety and enhanced surveillance. The timely and coordinated execution of these post-efficacy tasks will bring the pandemic to an effective, and efficient, close.

在最近几家制造商在临床试验中宣布了 COVID-19 疫苗在预防严重疾病方面的有效性之后，现在需要制定一项全面的后效战略，以确保全球人口接种疫苗。这些考虑应包括如何生产数十亿剂优质疫苗、对疫苗采购的支持、供应协调、疫苗的公平分配和全球疫苗交付的物流，所有这些都是针对大规模疫苗接种运动的前奏各个年龄段的人。此外，关于疫苗的其他科学问题仍需回答以提高疫苗效力，包括有关疫苗接种方案优化、加强剂量、保护相关性、疫苗有效性、安全和加强监控。这些效后任务的及时、协调执行，将使大流行有效、高效地结束。