Abstract

A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds. On the basis of spectroscopic data, they were determined to be ent-pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC₅₀ value at 62.56 μM and compared with the positive control minocycline (IC₅₀ 32.84 μM).

中文翻译：

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Sigesbeckia K 和 L，两种来自 Sigesbeckia glabrescens 的新型二萜类化合物，具有抗炎活性

摘要

Sigesbeckia glabrescens Makino的化学研究确定了四种化合物。根据光谱数据，它们被确定为ent -pimarane 型二萜及其类似物，其中有两种以前未描述的化合物 Sigesbeckia K ( 1 ) 和 Sigesbeckia L ( 2 )。通过测试它们对 BV2 小胶质细胞中 LPS 诱导的 NO 产生的抑制作用来评估这些化合物的抗炎作用，这揭示了潜在的抑制作用，IC ₅₀值为 62.56 μM，并与阳性对照米诺环素 (IC ₅₀ 32.84 μM)进行比较.