Abstract

Background

Folic acid was investigated for decreased concentrations of the same type of cysteine (Hcy), which is considered a risk factor for Alzheimer's disease. However, the conclusions are inconsistent, while supplementing elders with different folic acid states.

Method

The PubMed, Science Network and EMBASE databases were searched for randomized controlled trials published over the past decade; The 11/485 study was included on the basis of pre-defined criteria. Cognitive-related results, including cognitive function and brain atrophy, were measured using cognitive scales and magnetic resonance imaging.

Results

Significant cognitive benefits were reported in individuals with incomplete folic acid (n s 4); However, individuals with sufficient folic acid (n s 2) do not benefit from supplements, evaluated by the cognitive scale. On the other hand, a significant positive association was established in the participants of plasma Hcy, but the folic acid state was sufficient (n s 2). One study reported that folic acid supplements did not provide any benefit, but folic acid status data were missing. In addition, folic acid supplementation also improves brain atrophy (n s 2).

Conclusion

Baseline folic acid status may be a potential factor affecting the results of cognitive function folic acid supplementation in older adults. Older people with insufficient folic acid will benefit from folic acid supplementation.

中文翻译：

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基线叶酸状态影响叶酸补充剂在老年人认知相关结果中的有效性：系统评价

摘要

背景

研究叶酸以降低相同类型的半胱氨酸 (Hcy) 的浓度，这被认为是阿尔茨海默病的危险因素。但结论不一致，同时补充不同叶酸状态的长者。

方法

在 PubMed、Science Network 和 EMBASE 数据库中搜索了过去十年发表的随机对照试验；11/485 研究是根据预先定义的标准纳入的。使用认知量表和磁共振成像测量认知相关结果，包括认知功能和脑萎缩。

结果

在叶酸不完全的个体中报告了显着的认知益处（n s 4）；然而，通过认知量表评估，具有足够叶酸 (n s 2) 的个体不会从补充剂中受益。另一方面，在血浆 Hcy 的参与者中建立了显着的正相关，但叶酸状态是足够的（n s 2）。一项研究报告说，叶酸补充剂没有提供任何益处，但叶酸状态数据缺失。此外，补充叶酸还可以改善脑萎缩（n s 2）。

结论

基线叶酸状态可能是影响老年人认知功能叶酸补充结果的潜在因素。叶酸不足的老年人将受益于叶酸补充剂。