Synthesis of Difluorinated Dihydrobenzo[de]chromenes via Rh(III)‐Catalysed C‐H Couplings of 1‐Naphthols with Gem‐Difluoromethylene Alkynes,Advanced Synthesis & Catalysis

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Synthesis of Difluorinated Dihydrobenzo[de]chromenes via Rh(III)‐Catalysed C‐H Couplings of 1‐Naphthols with Gem‐Difluoromethylene Alkynes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-01-18 , DOI: 10.1002/adsc.202001475
Liping Li ₁ , Xiuhua Zhong ₂ , Jiali Xu ₂ , Hui Gao ₃ , Zhi Zhou ₄ , Wei Yi ₁

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The Rh(III)‐catalysed C−H couplings of 1‐naphthols with gem‐difluoromethylene alkynes have been realized for the direct construction of difluorinated dihydrobenzo[de]chromenes with broad substrate/functional group compatibility and good regio‐/chemoselectivity and in an atom‐economic manner. The unique fluorine effects account for the unconventional reaction path involving intramolecular 1,3‐hydrogen migration process to afford the exo‐methylene fragment.

中文翻译：

铑（III）催化1-萘酚与宝石-二氟亚甲基炔烃的C-H偶合反应合成二氟二氢苯并[de]色烯

已经实现了1-萘酚与宝石-二氟亚甲基炔烃的Rh（III）催化的CH偶联，可直接构建具有广泛的底物/官能团相容性和良好的区域/化学选择性的二氟化二氢苯并[ de ]苯二甲基苯。原子经济方式。独特的氟效应解释了涉及分子内1,3-氢迁移过程的非常规反应路径，从而提供了外亚甲基片段。

更新日期：2021-03-03

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