A U-shaped association between baseline neutrophil count and COVID-19-related mortality: A retrospective cohort study,Journal of Medical Virology

当前位置： X-MOL 学术 › J. Med. Virol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A U-shaped association between baseline neutrophil count and COVID-19-related mortality: A retrospective cohort study
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2021-01-19 , DOI: 10.1002/jmv.26794
Wei Fu ₁ , Chi Chen ₂ , Xin-Lin Chen ₃ , Kun Wang ₄ , Peiyuan Zuo ₅ , Yuwei Liu ₆ , Meng Zhang ₄ , Xiaofang Zhao ₄ , Songpu Xie ₄ , Hao Zhang ₄ , Yan Geng ₇ , Chengyun Liu ₄

Affiliation

Several descriptive studies have reported that higher neutrophil count (NC) may be correlated with poor prognosis in patients with confirmed COVID-19 infection. However, the findings from these studies are limited by methodology and data analysis. This study is a cohort study. We nonselectively and consecutively collected a total of 663 participants in a Chinese hospital from January 7 to February 28. Standardized and two-piecewise Cox regression model were employed to evaluate the association between baseline neutrophil count (bNC), neutrophil count change rate (NCR), and death. bNC had a U-shaped association with death. In the range of 0.1 to ≤1.49 × 10⁹/L (hazard ratio [HR] = 0.19, 95% confidence interval [CI] = 0.05–0.66) and >3.55 × 10⁹/L of bNC (HR = 2.82, 95% CI = 1.19–6.67), the trends on bNC with mortality were opposite. By recursive algorithm, the bNC at which the risk of the death was lower in the range of >1.49 to ≤3.55 × 10⁹/L (HR = 13.64, 95% CI = 0.25–74.71). In addition, we find that NCRs (NCR1 and NCR2) are not associated with COVID-19-related deaths. Compared with NCR, bNC has the potential to be used for early risk stratification in patients with COVID-19 infection. The relationship between bNC and mortality was U-shaped. The safe range of bNC was 1.64–4.0 × 10⁹/L. Identifying the correlation may be helpful for early risk stratification and medical decision-making.

更新日期：2021-01-19

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11