A nested longitudinal study within theAsymptomatic novel CORonavirus iNFfection study followed participants with positive nasopharyngeal swab to query for development of symptoms and assess duration of positive reverse transcription‐polymerase chain reaction (RT‐PCR) test results. Of the 91 participants initially testing positive, 86 participated in follow‐up approximately 14 days after study enrollment; of those 86 participants, 19 (22.1%) developed at least one symptom at any time after the initial positive severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) test result. The median number of days to symptom development after their initial positive test result was 6 (range 1–29 days). No participants reported a SARS‐CoV‐2‐related hospitalization. The most frequently reported symptoms were fatigue or muscle aches (10.5%), headache (9.3%), fever (5.8%), and shortness of breath (5.8%). Of the 78 participants who submitted a nasopharyngeal swab for repeat RT‐PCR testing, 17 (21.8%) remained positive at Day 14, 4 of which continued to test positive at Day 28. These findings reinforce the probable role of silent SARS‐CoV‐2 infections in community transmission, and that reliance on symptom development will miss a large proportion of infections. Broad testing programs not limited to individuals presenting with symptoms are critical for identifying persons with SARS‐CoV‐2 infection and ultimately slowing transmission.

中文翻译：

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无症状新型冠状病毒感染研究中 SARS-CoV-2 阳性亚组的随访


无症状新型冠状病毒感染研究中的一项嵌套纵向研究对鼻咽拭子呈阳性的参与者进行跟踪，以询问症状的发展并评估阳性逆转录聚合酶链反应（RT-PCR）检测结果的持续时间。在最初检测呈阳性的 91 名参与者中，有 86 名参与者在研究入组后约 14 天参与了随访；在这 86 名参与者中，有 19 人 (22.1%) 在首次严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 检测结果呈阳性后的任何时间出现至少一种症状。初次检测结果呈阳性后到出现症状的中位天数为 6 天（范围 1-29 天）。没有参与者报告与 SARS-CoV-2 相关的住院治疗。最常报告的症状是疲劳或肌肉疼痛（10.5%）、头痛（9.3%）、发烧（5.8%）和呼吸短促（5.8%）。在提交鼻咽拭子进行重复 RT-PCR 检测的 78 名参与者中，17 人 (21.8%) 在第 14 天仍呈阳性，其中 4 人在第 28 天继续检测呈阳性。这些发现强化了沉默 SARS-CoV- 的可能作用。 2 感染在社区传播，并且依靠症状发展会漏掉很大一部分感染。广泛的检测计划不仅限于出现症状的个人，对于识别 SARS-CoV-2 感染者并最终减缓传播至关重要。