Rotaviruses are the dominant cause of severe acute gastroenteritis in children under 5 years of age. Previous studies showed that some children are less susceptible to rotavirus gastroenteritis. It has been shown that this resistance depends on the rotavirus genotype and also human histo-blood group antigens (HBGAs), which works as a receptor for rotavirus surface protein (VP4). The present study aimed to evaluate the human genetic susceptibility to rotavirus gastroenteritis in Iran and to obtain a comparative analysis between rotavirus gastroenteritis and secretor or Lewis status in case and control groups in the Iranian population. The study was performed on fecal specimens from 108 children with acute rotavirus gastroenteritis from 2015 to 2017. A total of 50 fecal specimens from children with acute gastroenteritis of unknown etiology were also used as a control group. After the genotyping of positive rotavirus cases and human HBGAs by Sanger sequencing, the phylogenetic tree analysis showed that all rotavirus strains from Iran belonged to P[II]. The most common genotype was P[8] (n = 102; 94.4%), while the remaining belonged to P[4] (n = 3; 2.8%) and P[6] (n = 3; 2.8%) genotypes. The P[8] genotype was found to be associated with secretor and Lewis positive status (p < .05).

中文翻译：

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伊朗急性胃肠炎住院患儿循环轮状病毒基因型与组织血型抗原的相关性

轮状病毒是 5 岁以下儿童严重急性胃肠炎的主要原因。之前的研究表明，一些儿童不太容易感染轮状病毒肠胃炎。已经表明，这种抗性取决于轮状病毒基因型以及人类组织血型抗原 (HBGA)，后者充当轮状病毒表面蛋白 (VP4) 的受体。本研究旨在评估伊朗人对轮状病毒胃肠炎的遗传易感性，并在伊朗人群的病例组和对照组中对轮状病毒胃肠炎与分泌型或路易斯状态进行比较分析。该研究对 2015 年至 2017 年 108 名患有急性轮状病毒胃肠炎的儿童的粪便标本进行了研究。50份不明原因急性胃肠炎患儿的粪便标本也作为对照组。通过桑格测序对轮状病毒阳性病例和人类HBGAs进行基因分型后，系统发育树分析表明，伊朗所有轮状病毒株均属于P[II]。最常见的基因型是 P[8] (n  = 102；94.4%)，而其余属于 P[4] ( n  = 3; 2.8%) 和 P[6] ( n  = 3; 2.8%) 基因型。发现 P[8] 基因型与分泌型和 Lewis 阳性状态有关 ( p  < .05)。