Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% were Enterovirus B and 9% were Enterovirus A species. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV-B5), CV-B6, E21, and EV-B69 were only seen in patients with residual paralysis. Analyses of the EV-A71 sequence indicated a unique genogroup.

中文翻译：

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从乌干达急性弛缓性麻痹患者中分离出的非脊髓灰质炎肠道病毒的分子特征

肠道病毒 (EV) 是 RNA 病毒，可引起许多临床综合征，包括急性弛缓性麻痹 (AFP)。在全球脊髓灰质炎实验室网络中，EV 被归类为脊髓灰质炎病毒或非脊髓灰质炎肠道病毒 (NPEV)。已经在 AFP 患者的脊髓灰质炎样残留麻痹事件中描述了特定的 NPEV。对来自 AFP 患者的 112 株 NPEV 分离株进行回顾性分析，鉴定出 31 种 NPEV 类型，其中 91% 为肠病毒 B，9% 为肠病毒 A物种。NPEVs分布在全国各地，东部地区患者最多（41/89；46.1%）。患者比例最高的是 5 岁以下儿童 (77/89; 86.5%)，男性患者更常见 (54/89; 60.7%)。Echovirus 11 (11/89; 12.4%) 经常被观察到，这些序列的系统发育分析揭示了高度的多样性。柯萨奇病毒 B5 (CV-B5)、CV-B6、E21 和 EV-B69 仅见于残余麻痹患者。对 EV-A71 序列的分析表明了一个独特的基因组。