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Effect of ginger (Zingiber officinale) supplementation on oxidative stress parameters: A systematic review and meta‐analysis
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-01-17 , DOI: 10.1111/jfbc.13612 Mojgan Morvaridzadeh 1 , Ehsan Sadeghi 2 , Shahram Agah 3 , Siavash Fazelian 4 , Mehran Rahimlou 5 , Ferdinand Georg Kern 6 , Shilan Heshmati 1 , Amirhosein Omidi 1 , Emma Persad 7 , Javad Heshmati 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-01-17 , DOI: 10.1111/jfbc.13612 Mojgan Morvaridzadeh 1 , Ehsan Sadeghi 2 , Shahram Agah 3 , Siavash Fazelian 4 , Mehran Rahimlou 5 , Ferdinand Georg Kern 6 , Shilan Heshmati 1 , Amirhosein Omidi 1 , Emma Persad 7 , Javad Heshmati 1
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A wide variety of antioxidant properties are attributed to ginger (Zingiber officinale) and several randomized controlled trials (RCTs) have investigated the effect of ginger intake on major oxidative stress (OS) parameters. We conducted a systematic review and meta‐analysis to evaluate the effects of using ginger to improve OS levels. Medline, Scopus, ISI Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched up until March 2020 to gather RCTs that evaluated the impact of ginger intake on the levels and activity of OS parameters in adult subjects. Means and standard deviations for relevant OS variables were extracted and evaluated to assess the quality of the trials based on the Cochrane risk‐of‐bias tool for randomized trials. The gathered data were pooled and expressed as standardized mean difference (SMD) with 95% Confidence Intervals (95% CI). Twelve trials were included in this review. Ginger intake was shown to significantly increase glutathione peroxidase (GPx) activity (SMD: 1.64; 95% CI: 0.43, 2.85; I2 = 86.8%) and total antioxidant capacity (TAC) (SMD: 0.40; 95% CI: 0.06, 0.73; I2 = 42.8%) and significantly decrease malondialdehyde (MDA) levels (SMD: −0.69; 95% CI: −1.26, −0.12; I2 = 85.8%) compared to control groups. Ginger supplementation also non‐significantly associated with an increase in CAT activity (SMD: 1.09; 95% CI: −0.07, 2.25; I2 = 87.6%). This systematic review and meta‐analysis presents convincing evidence supporting the efficacy of ginger supplementation on improving OS levels.
中文翻译：
生姜补充剂对氧化应激参数的影响：系统评价和荟萃分析
生姜（ Zingiber officinale ）具有多种抗氧化特性，多项随机对照试验（RCT）研究了生姜摄入量对主要氧化应激（OS）参数的影响。我们进行了系统回顾和荟萃分析，以评估使用生姜提高 OS 水平的效果。截至 2020 年 3 月，系统地检索了 Medline、Scopus、ISI Web of Science、EMBASE 和 Cochrane 对照试验中央注册库，以收集评估生姜摄入量对成人受试者 OS 参数水平和活性影响的随机对照试验。提取并评估相关 OS 变量的平均值和标准差，以根据随机试验的 Cochrane 偏倚风险工具评估试验的质量。收集的数据被汇总并表示为标准化平均差 (SMD)，置信区间为 95% (95% CI)。本次评价纳入了 12 项试验。摄入生姜可显着提高谷胱甘肽过氧化物酶 (GPx) 活性（SMD：1.64；95% CI：0.43、2.85； I 2 = 86.8%）和总抗氧化能力（TAC）（SMD：0.40；95% CI：0.06，与对照组相比，显着降低丙二醛（MDA）水平（SMD：-0.69；95% CI：-1.26，-0.12；I 2 = 85.8%） 。补充生姜也与 CAT 活性的增加不显着相关（SMD：1.09；95% CI：-0.07, 2.25； I 2 = 87.6%）。这项系统评价和荟萃分析提供了令人信服的证据，支持生姜补充剂对提高 OS 水平的功效。
更新日期：2021-02-22
中文翻译：
生姜补充剂对氧化应激参数的影响：系统评价和荟萃分析
生姜（ Zingiber officinale ）具有多种抗氧化特性，多项随机对照试验（RCT）研究了生姜摄入量对主要氧化应激（OS）参数的影响。我们进行了系统回顾和荟萃分析，以评估使用生姜提高 OS 水平的效果。截至 2020 年 3 月，系统地检索了 Medline、Scopus、ISI Web of Science、EMBASE 和 Cochrane 对照试验中央注册库，以收集评估生姜摄入量对成人受试者 OS 参数水平和活性影响的随机对照试验。提取并评估相关 OS 变量的平均值和标准差，以根据随机试验的 Cochrane 偏倚风险工具评估试验的质量。收集的数据被汇总并表示为标准化平均差 (SMD)，置信区间为 95% (95% CI)。本次评价纳入了 12 项试验。摄入生姜可显着提高谷胱甘肽过氧化物酶 (GPx) 活性（SMD：1.64；95% CI：0.43、2.85； I 2 = 86.8%）和总抗氧化能力（TAC）（SMD：0.40；95% CI：0.06，与对照组相比，显着降低丙二醛（MDA）水平（SMD：-0.69；95% CI：-1.26，-0.12；I 2 = 85.8%） 。补充生姜也与 CAT 活性的增加不显着相关（SMD：1.09；95% CI：-0.07, 2.25； I 2 = 87.6%）。这项系统评价和荟萃分析提供了令人信服的证据，支持生姜补充剂对提高 OS 水平的功效。
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