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Chemical Composition and Cytotoxic Evaluation of the Essential Oil of Phyllogonium viride Brid. (Phyllogoniaceae, Bryophyta)
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-01-18 , DOI: 10.1002/cbdv.202000794 Christchellyn Klegin 1 , Neusa Fernandes de Moura 2 , Matheus Henrique Oliveira de Sousa 2 , Rafaele Frassini 3 , Mariana Roesch-Ely 3 , Alessandra Nejar Bruno 4 , Thais Cardoso Bitencourt 4 , Adriana Flach 5 , Juçara Bordin 1, 6
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-01-18 , DOI: 10.1002/cbdv.202000794 Christchellyn Klegin 1 , Neusa Fernandes de Moura 2 , Matheus Henrique Oliveira de Sousa 2 , Rafaele Frassini 3 , Mariana Roesch-Ely 3 , Alessandra Nejar Bruno 4 , Thais Cardoso Bitencourt 4 , Adriana Flach 5 , Juçara Bordin 1, 6
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The present study aimed to determine the chemical composition and biological activity of the essential oil obtained from Phyllogoniun viride Brid.(Phyllogoniaceae, Bryophyta), whose samples were collected in southern Brazil. The cytotoxic activity of the essential oil of P. viride in breast and colorectal tumor cells (MCF-7 and HCT-116) was evaluated, as well as the cytotoxic potential of this oil in non-tumoral cells of human immortalized keratinocytes (HaCaT) via MTT assay. The major compounds found in the essential oil of P. viride were β-bazzanene (20.30%), β-caryophyllene (17.06%), β-chamigrene (14.02), and Germacrene B (11.72%). Treatment with the essential oil of P. viride in the different cell lines tested did not induce toxicity in the vast majority of the tested concentrations. These data contribute to the generation of new scientific data about this little-studied plant species. Besides, the chemical characterization of the compounds present in the essential oil of P. viride can lead to a greater elucidation of the biotechnological potential of the same.
中文翻译：
绿叶根香精油的化学成分和细胞毒性评价。（木门科，苔藓植物）
本研究旨在确定从绿叶蕨类植物（Phylllogoniaceae，Bryophyta）中提取的精油的化学成分和生物活性，其样品采集于巴西南部。评估了绿色假单胞菌精油在乳腺和结直肠肿瘤细胞（MCF-7 和 HCT-116）中的细胞毒活性，以及该精油在人永生化角质形成细胞 (HaCaT) 的非肿瘤细胞中的细胞毒潜力通过 MTT 测定。P. viride 精油中发现的主要化合物是 β-bazzanene (20.30%)、β-石竹烯 (17.06%)、β-chamigrene (14.02) 和 Germacrene B (11.72%)。在测试的不同细胞系中用绿色假单胞菌精油处理在绝大多数测试浓度下没有诱导毒性。这些数据有助于生成关于这种鲜为人知的植物物种的新科学数据。此外，绿色假单胞菌精油中存在的化合物的化学特征可以更好地阐明其生物技术潜力。
更新日期：2021-01-18
中文翻译：
绿叶根香精油的化学成分和细胞毒性评价。（木门科，苔藓植物）
本研究旨在确定从绿叶蕨类植物（Phylllogoniaceae，Bryophyta）中提取的精油的化学成分和生物活性，其样品采集于巴西南部。评估了绿色假单胞菌精油在乳腺和结直肠肿瘤细胞（MCF-7 和 HCT-116）中的细胞毒活性，以及该精油在人永生化角质形成细胞 (HaCaT) 的非肿瘤细胞中的细胞毒潜力通过 MTT 测定。P. viride 精油中发现的主要化合物是 β-bazzanene (20.30%)、β-石竹烯 (17.06%)、β-chamigrene (14.02) 和 Germacrene B (11.72%)。在测试的不同细胞系中用绿色假单胞菌精油处理在绝大多数测试浓度下没有诱导毒性。这些数据有助于生成关于这种鲜为人知的植物物种的新科学数据。此外，绿色假单胞菌精油中存在的化合物的化学特征可以更好地阐明其生物技术潜力。
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