Atom‐Economic Alk(en)ylations of Esters, Amides, and Methyl Heteroarenes Utilizing Alcohols Following Dehydrogenative Strategies,Asian Journal of Organic Chemistry

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Atom‐Economic Alk(en)ylations of Esters, Amides, and Methyl Heteroarenes Utilizing Alcohols Following Dehydrogenative Strategies
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-01-18 , DOI: 10.1002/ajoc.202000634
Siva Nagendra Reddy Donthireddy ₁ , Chandra Shekhar Tiwari ₁ , Shashi Kumar ₁ , Arnab Rit ₂

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Owing to the atom‐economic and greener nature, borrowing hydrogen (BH) and acceptorless dehydrogenative coupling (ADC) processes have drawn significant attentions of the researchers across the globe and thus, these strategies have been extensively utilized in synthetic chemistry to access various challenging and valuable compounds. During the last decade, significant progress has been witnessed in the utilization of these protocols involving alkylation of amides/esters/N‐heteroarenes by replacing the traditionally utilized mutagenic reagents as alkyl source with the sustainable biomass derived alcohols under BH/ADC process. This progress includes mainly the transition metal based catalytic systems although a few metal‐free protocols are reported. In this minireview, the advancement from 2010 until September 2020 in accessing C‐alk(en)ylated compounds from the unactivated amides/esters/N‐heteroarenes utilizing alcohols via BH/ADC strategy is highlighted. Additionally, a few reports on aldehydes instead of alcohols as coupling partners are also discussed.

中文翻译：

遵循脱氢策略后，利用醇的酯，酰胺和甲基杂芳烃的原子经济烷基化

由于原子经济和绿色的性质，借用氢（BH）和无受体脱氢偶联（ADC）工艺引起了全球研究人员的极大关注，因此，这些策略已在合成化学中得到广泛利用，以应对各种挑战性和挑战性问题。有价值的化合物。在过去的十年中，通过在BH / ADC过程中用可持续的生物质衍生醇替代传统使用的诱变试剂作为烷基源，在利用酰胺/酯/ N-杂芳烃烷基化这些方案的过程中已取得了显着进展。该进展主要包括基于过渡金属的催化体系，尽管据报道一些无金属的方案。在这份迷你评论中，通过BH / ADC策略突出显示。此外，还讨论了一些有关醛而不是醇作为偶联伙伴的报道。

更新日期：2021-03-11

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