The stratigraphic sequences of numerous Palaeolithic sites of Central and Southern Italy, very rich in both archaeological and palaeontological remains, have also recorded Pleistocene volcanic events through volcanic ash deposits (tephra). They allow the establishment of an accurate chronological framework by comparing results obtained by ⁴⁰Ar/³⁹Ar dating method on single volcanic K-feldspar crystals, with those derived from ESR and ESR/U-series analyses on fluvial bleached quartz and tooth enamel respectively.

Since 2009, these three methods were hence applied on samples of several Middle Pleistocene sites of Central and Southern Italy including both volcanic and archaeological levels (from the west to the east): La Polledrara di Cecanibbio, Isoletta, (Latium), Guado San Nicola, Isernia La Pineta (Molise), Valle Giumentina (Abruzzo) and Venosa Notarchirico (Basilicata).

The obtained results, covering a time range from 660 to 350 ka, prove that such a multi-method approach when possible is essential to constrain the chronology of each site and allow the recognition of the specific limitations due to the lack of quartz for ESR or to complex geochemical histories in teeth rendering difficult the ESR/U-series method. Despite these limitations, the ESR framework is globally in agreement with the ⁴⁰Ar/³⁹Ar chronology, while ESR/U-series dates can be underestimated for the oldest sites. In such cases, an isochron approach attests however of the quite good reliability of the palaeodosimetric reconstruction and the observed age underestimation could be related to other factors affecting the ESR age determination.

意大利中部和南部的许多旧石器时代遗址的地层层序，都非常丰富，既有考古遗迹也有古生物学遗迹，还通过火山灰沉积物（tephra）记录了更新世的火山事件。通过比较单个火山钾长石晶体的⁴⁰ Ar / ³⁹ Ar测年方法获得的结果，以及分别对河流漂白石英和牙釉质进行ESR和ESR / U系列分析得出的结果，他们可以建立一个准确的时间框架。

自2009年以来，这三种方法因此应用于意大利中部和南部几个中更新世遗址的样本，包括火山和考古级别（从西到东）：La Polledrara di Cecanibbio，Isoletta（（镭）），Guado San Nicola ，Isernia La Pineta（莫利塞），Valle Giumentina（阿布鲁佐）和Venosa Notarchirico（巴西利卡塔）。

所获得的结果涵盖了从660到350 ka的时间范围，证明了这种多方法方法对于限制每个站点的时间顺序是必要的，并且由于缺少ESR或ESR的石英，因此可以识别特定的限制。牙齿中复杂的地球化学历史使得ESR / U系列方法变得困难。尽管存在这些限制，但ESR框架在全球范围内与⁴⁰ Ar / ³⁹ Ar年表一致，而对于最早的站点，ESR / U系列日期可能会被低估。在这种情况下，等时方法证明了古剂量重建的可靠性非常好，并且观察到的年龄低估可能与影响ESR年龄确定的其他因素有关。