Alginate based gels are widely adopted in many pharmaceutical and biomedical fields. The main rheological characteristics of the alginate-based gels are important design parameters for gel preparation. A new methodology for rheological tests on the alginate-based gels has been assessed in order to obtain reliable and reproducible results in terms of loss and storage moduli. The methodology accounts for the effect of morphology on the rheological properties. Reliable results can be achieved if the structure of the gel is preserved during the analysis, thus, the control of the load applied during the rheological test plays a crucial role. The application of the proposed methodology allows to obtain information about the cross-linking degree of hydrogels. To this purpose, hydrogels with different ratios of divalent cations and alginate have been adopted. The number of junctions in the network formed during the cross-linking process has been evaluated and the results are consistent with the infrared analysis conducted on the same hydrogels.

基于海藻酸盐的凝胶在许多制药和生物医学领域中被广泛采用。基于藻酸盐的凝胶的主要流变特性是凝胶制备的重要设计参数。为了获得在损失和储能模量方面可靠且可重现的结果，已经评估了对基于藻酸盐的凝胶进行流变学测试的新方法。该方法考虑了形态学对流变性质的影响。如果在分析过程中保留凝胶的结构，则可以获得可靠的结果，因此，控制流变测试过程中施加的载荷起着至关重要的作用。所提出的方法的应用允许获得有关水凝胶的交联度的信息。为此，已经采用了具有不同比例的二价阳离子和藻酸盐的水凝胶。已经评估了在交联过程中形成的网络中结的数量，其结果与对同一水凝胶进行的红外分析一致。