Bone Tissue Engineering has been focusing on improving the current methods for bone repair, being the use of scaffolds presented as an upgrade to traditional surgery techniques. Scaffolds are artificially porous matrices, meant to promote cell seeding and proliferation, being these properties influenced by the permeability of the structure. This work employed experimental pressure drop tests and Computational Fluid Dynamics models to assess permeability (and fluid streamlines) within different triply periodic minimal surfaces scaffold geometries (Schwarz D, Gyroid and Schwarz P). The pressure outputs from the computational analysis presented a good correlation with the experimental results, with R² equal to 0.903; they have also shown that a lower porosity may not mean a lower permeability if the geometry is altered, such as the difference between 60% porous Gyroid scaffolds (8.1*10^-9 mm²) and 70% porous Schwarz D scaffolds (7.1*10^-9 mm²). Fluid streamlines revealed how the Gyroid geometries are the most appropriate design for most bone tissue engineering applications, due to their consistent fluid permeation, followed by Schwarz D. The Schwarz P geometries have shown flat streamlines and significant variation of the permeability with the porosity (an increase of 10% in their porosity lead to an increase in the permeability from 5.1*10^-9 mm² to 11.7*10^-9 mm²), which would imply a poor environment for cell seeding and proliferation.

骨组织工程一直致力于改善当前的骨修复方法，即使用支架作为对传统手术技术的升级。支架是人工多孔的基质，旨在促进细胞播种和增殖，因为这些特性会受到结构渗透性的影响。这项工作采用了实验压降测试和计算流体动力学模型来评估在不同的三重周期性最小表面支架几何结构（Schwarz D，Gyroid和Schwarz P）中的渗透率（和流体流线）。计算分析的压力输出与实验结果具有良好的相关性，R ²等于0.903; 他们还表明，如果改变几何形状，则较低的孔隙度可能并不意味着较低的渗透性，例如60％多孔Gyroid支架（8.1 * 10 ^-9 mm ²）和70％多孔Schwarz D支架（7.1 * 10）之间的差异^-9 mm ²）。流体流线揭示了Gyroid几何形状对于大多数骨组织工程应用而言是最合适的设计，这是由于其一致的流体渗透性，其次是SchwarzD。SchwarzP几何形状显示出平坦的流线形状以及渗透率随孔隙率的显着变化（孔隙率增加10％会使渗透率从5.1 * 10 ^-9 mm ²增加到11.7 * 10 ^-9（mm ²），这暗示着细胞播种和增殖的不良环境。