Conventional drug administrations are associated with low bioavailability, high cost, more side effects, uncontrolled release profile, and patient noncompliance. Therefore, the development of an alternative to traditional drug delivery systems (DDSs) is of crucial significance. Up to now, various materials have been investigated for these purposes, among them, carboxymethyl starch (CMS) owing to its specific advantages has been studied for extensively drug delivery, particularly for oral administration. This review for the first time provides an outline of the CMS application in all areas of drug delivery. Thus, the major focus of this review is the detailed highlighting of the recent advances in CMS based DDSs to offer comprehensive information for overcoming traditional DDSs. The perspectives and the challenges of the CMS-based DDSs are briefly commented as well as. Hopefully, the current review will help to promotion of new innovative types of CMS-based systems for drug delivery applications in the near future.

常规药物施用与低生物利用度，高成本，更多副作用，释放控制不受控制以及患者不依从有关。因此，开发替代传统药物递送系统（DDS）的方法至关重要。迄今为止，已经研究了用于这些目的的各种材料，其中，由于羧甲基淀粉（CMS）的特殊优点，已经对其进行了广泛的药物递送，特别是口服给药的研究。这篇综述首次概述了CMS在所有药物输送领域中的应用。因此，本文的重点是详细介绍基于CMS的DDS的最新进展，以提供克服传统DDS的全面信息。还简要评论了基于CMS的DDS的观点和挑战。希望当前的审查将有助于在不久的将来推广用于药物输送应用的新型创新型基于CMS的系统。