It is difficult to obtain stable multifunctional silver-containing materials that are suitable for use as wound dressings. To solve this problem, we added graphene oxide (GO) to an acetobacter culture medium and used a biological blending self-growth method to fix GO onto the bacterial cellulose to form a mixed-growth film. We then used polydopamine to fix AgNPs to obtain a novel silver-based cellulose wound dressing. This composite material was characterized by infrared spectroscopy, electron microscopy, and X-ray diffractometry, and the results showed that silver nanoparticles uniformly covered the material surface, while graphene was wrapped in a layer of bacterial cellulose. This composite film was conductive and produced a weak current, and it generated heat when a voltage was applied. This allowed it to accelerate wound cell migration and promote wound healing. In addition, AgNPs immobilized on the surface released Ag⁺, which generated a large number of oxidizing free radicals that killed and bacteria. The in vitro cytotoxicity tests showed that the Ag-pDA/BC (rGO) composite film has excellent biocompatibility, giving it good application prospects for wound dressings.

难以获得适合用作伤口敷料的稳定的多功能含银材料。为解决此问题，我们在醋杆菌属细菌培养基中添加了氧化石墨烯（GO），并使用生物共混自生长方法将GO固定在细菌纤维素上，以形成混合生长膜。然后，我们使用聚多巴胺固定AgNPs，以获得新型的银基纤维素伤口敷料。通过红外光谱，电子显微镜和X射线衍射对这种复合材料进行了表征，结果表明，银纳米颗粒均匀地覆盖了材料表面，而石墨烯则包裹在一层细菌纤维素中。该复合膜是导电的并且产生微弱的电流，并且当施加电压时其产生热量。这使其可以加速伤口细胞迁移并促进伤口愈合。另外，固定在表面上的AgNPs释放出Ag⁺产生大量的氧化性自由基，可杀死细菌。在体外细胞毒性试验表明，所述Ag-PDA / BC（RGO）复合膜具有优良的生物相容性，赋予其为伤口敷料很好的应用前景。