Glioma is the most prevalent intracranial tumour, with considerable morbidity. Long non-coding RNAs are important in the biological processes of various cancers. However, little is known about ST7 antisense RNA 1 (ST7-AS1) and its role in glioma progression. ST7-AS1 expression was reduced in glioma tissues and cells in comparison to normal brain tissues. p53 transcriptionally targeted the ST7-AS1 promoter in U251 glioma cells. The targeting significantly inhibited cell migration, invasion, and proliferation, and promoted apoptosis. ST7-AS1 directly bound to and downregulated polypyrimidine tract-binding protein 1 (PTBP1) at the post-transcriptional level. ST7-AS1 overexpression inhibited glioma progression by suppressing Wnt/β-catenin signalling by downregulating PTBP1 expression. Additionally, p53 expression negatively correlated with PTBP1 expression. Glioma progression is regulated by a positive feedback loop involving the p53/ST7-AS1/PTBP1 axis, which might be a promising therapeutic target for glioma treatment.

胶质瘤是最常见的颅内肿瘤，发病率相当高。长链非编码 RNA 在各种癌症的生物学过程中很重要。然而，对 ST7 反义 RNA 1 (ST7-AS1) 及其在胶质瘤进展中的作用知之甚少。与正常脑组织相比，胶质瘤组织和细胞中的 ST7-AS1 表达降低。p53 转录靶向 U251 神经胶质瘤细胞中的 ST7-AS1 启动子。靶向作用显着抑制细胞迁移、侵袭和增殖，促进细胞凋亡。ST7-AS1 在转录后水平直接结合并下调聚嘧啶束结合蛋白 1 (PTBP1)。ST7-AS1 过表达通过下调 PTBP1 表达来抑制 Wnt/β-catenin 信号传导，从而抑制胶质瘤进展。此外，p53 表达与 PTBP1 表达负相关。胶质瘤进展受涉及 p53/ST7-AS1/PTBP1 轴的正反馈回路调节，这可能是胶质瘤治疗的一个有希望的治疗靶点。