The Journal of Membrane Biology ( IF 2.3 ) Pub Date : 2021-01-19 , DOI: 10.1007/s00232-020-00164-9 Arijit Mahapatra 1 , Can Uysalel 1 , Padmini Rangamani 1
|
Abstract
Membrane tubulation is a ubiquitous process that occurs both at the plasma membrane and on the membranes of intracellular organelles. These tubulation events are known to be mediated by forces applied on the membrane either due to motor proteins, by polymerization of the cytoskeleton, or due to the interactions between membrane proteins binding onto the membrane. The numerous experimental observations of tube formation have been amply supported by mathematical modeling of the associated membrane mechanics and have provided insights into the force-displacement relationships of membrane tubes. Recent advances in quantitative biophysical measurements of membrane-protein interactions and tubule formation have necessitated the need for advances in modeling that will account for the interplay of multiple aspects of physics that occur simultaneously. Here, we present a comprehensive review of experimental observations of tubule formation and provide context from the framework of continuum modeling. Finally, we explore the scope for future research in this area with an emphasis on iterative modeling and experimental measurements that will enable us to expand our mechanistic understanding of tubulation processes in cells.
Graphic Abstract
中文翻译：
生物膜中小管形成的力学和热力学
摘要
膜管化是一种普遍存在的过程，发生在质膜和细胞内细胞器的膜上。已知这些管状事件是由施加在膜上的力介导的，或者是由于运动蛋白、通过细胞骨架的聚合，或者是由于结合到膜上的膜蛋白之间的相互作用。对管形成的大量实验观察得到了相关膜力学数学模型的充分支持，并为膜管的力-位移关系提供了见解。膜-蛋白质相互作用和小管形成的定量生物物理测量的最新进展需要建模方面的进步，以解释同时发生的物理多个方面的相互作用。在这里，我们对肾小管形成的实验观察进行了全面的回顾，并提供了连续体模型框架的背景。最后，我们探索了该领域未来研究的范围，重点是迭代建模和实验测量，这将使我们能够扩大对细胞管管过程的机械理解。
京公网安备 11010802027423号