Abstract

Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells.

Graphical abstract

中文翻译：

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大叶香豆心叶中的双吲哚生物碱

摘要

从大叶猴面包树的叶子中分离出两个新的双吲哚生物碱，12' - O-去甲基-伏丁胺-5-内酰胺和异伏他辛-N-氧化物（1和2），以及两个已知的双吲哚生物碱。根据1D和2D NMR数据阐明了它们的结构。图1和图2显示了对恶性疟原虫3D7的有效抗疟活性和对人细胞系HepG2细胞的非常低的细胞毒性活性。

图形概要