Reduced thalamic resting‐state functional connectivity and impaired cognition in acute abstinent heroin users,Human Brain Mapping

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Reduced thalamic resting‐state functional connectivity and impaired cognition in acute abstinent heroin users
Human Brain Mapping ( IF 3.5 ) Pub Date : 2021-01-18 , DOI: 10.1002/hbm.25346
Min Zhang _{1,

2} , Shuang Liu _{1,

2} , Shicong Wang _{1,

2} , Yan Xu _{1,

2} , Longmao Chen _{1,

2} , Ziqiang Shao _{1,

2} , Xinwen Wen _{1,

2} , Wenhan Yang ₃ , Jun Liu ₃ , Kai Yuan _{1,

2}

Affiliation

As a critical component of cortico‐striato‐thalamo‐cortical loop in addiction, our understanding of the thalamus in impaired cognition of heroin users (HU) has been limited. Due to the complex thalamic connection with cortical and subcortical regions, thalamus was divided into prefrontal (PFC), occipital (OC), premotor, primary motor, sensory, temporal, and posterior parietal association subregions according to white matter tractography. We adopted seven subregions of bilateral thalamus as regions of interest to systematically study the implications of distinct thalamic nuclei in acute abstinent HU. The volume and resting‐state functional connectivity (RSFC) differences of the thalamus were investigated between age‐, gender‐, and alcohol‐matched 37 HU and 33 healthy controls (HCs). Trail making test‐A (TMT‐A) was adopted to assess cognitive function deficits, which were then correlated with neuroimaging findings. Although no significant different volumes were found, HU group showed decreased RSFC between left PFC_thalamus and middle temporal gyrus as well as between left OC_thalamus and inferior frontal gyrus and supplementary motor area relative to HCs. Meanwhile, the higher TMT‐A scores in HU were negatively correlated with PFC_thalamic RSFC with inferior temporal gyrus, fusiform, and precuneus. Craving scores were negatively correlated with OC_thalamic RSFC with accumbens, hippocampus, and insula. Opiate Withdrawal Scale scores were negatively correlated with left PFC/OC_thalamic RSFC with orbitofrontal cortex and medial PFC. We indicated two thalamus subregions separately involvement in cognitive control and craving to reveal the implications of thalamic subnucleus in pathology of acute abstinent HU.

中文翻译：

急性戒断海洛因使用者丘脑静息态功能连接减少和认知受损

作为成瘾过程中皮质-纹状体-丘脑-皮质环路的关键组成部分，我们对海洛因使用者（HU）认知受损的丘脑的了解有限。由于丘脑与皮质和皮质下区域的复杂联系，根据白质纤维束描记，丘脑被分为前额叶（PFC）、枕叶（OC）、前运动、初级运动、感觉、颞叶和后顶叶关联亚区。我们采用双侧丘脑的七个亚区域作为感兴趣区域，系统地研究不同丘脑核在急性禁欲性尿毒症中的影响。研究了年龄、性别和酒精匹配的 37 名 HU 和 33 名健康对照 (HC) 之间丘脑的体积和静息状态功能连接 (RSFC) 差异。采用追踪测试-A（TMT-A）来评估认知功能缺陷，然后将其与神经影像学结果相关联。虽然没有发现显着的体积差异，但相对于 HC，HU 组显示左侧 PFC_丘脑和颞中回之间以及左侧 OC_丘脑和额下回以及辅助运动区之间的 RSFC 减少。同时，HU 中较高的 TMT-A 评分与 PFC_丘脑 RSFC 与颞下回、梭状回和楔前叶呈负相关。渴望得分与 OC_丘脑 RSFC 与伏隔核、海马体和岛叶呈负相关。阿片戒断量表评分与左侧 PFC/OC_丘脑 RSFC、眶额皮层和内侧 PFC 呈负相关。我们指出两个丘脑亚区分别参与认知控制和渴望，以揭示丘脑亚核在急性戒断性尿毒症病理学中的意义。

更新日期：2021-01-18

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