A light-activated nanotherapeutic with broad-spectrum bacterial recognition to eliminate drug-resistant pathogens,Journal of Materials Chemistry B

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A light-activated nanotherapeutic with broad-spectrum bacterial recognition to eliminate drug-resistant pathogens
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-31 , DOI: 10.1039/d0tb02583f
Xiaosong Wei _{1,

2,

3,

4,

5} , Yingchao Gao _{1,

2,

3,

4,

5} , Yuqing Hu _{1,

2,

3,

4,

5} , Yufei Zhang _{1,

2,

3,

4,

5} , Xinge Zhang _{1,

2,

3,

4,

5}

Affiliation

Obstinate infections caused by drug-resistant bacteria severely threaten human health. And the emergence of multidrug-resistant bacteria increases the morbidity and mortality of patients, thus necessitating the development of innovative or alternative therapeutics. Here, a light-activated nanotherapeutic with broad-spectrum bacterial recognition is established as an antibiotic-free therapeutic agent against pathogens. The nanotherapeutic with external phenylboronic acid-based glycopolymers increases the stability and biocompatibility and shows the ability of bacterial recognition. Once irradiated with near-infrared light, this nanotherapeutic with high photothermal conversion efficiency disrupts the cytoplasmic membrane, thus killing bacterial cells. Importantly, it also eliminates the biofilms formed by both drug-resistant Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus) effectively. Thus, this antibiotic-free nanotherapeutic with hypotoxicity offers a promising approach to fight increasingly serious antimicrobial resistance.

中文翻译：

具有广谱细菌识别功能的光活化纳米疗法，可消除耐药病原体

由耐药菌引起的顽固性感染严重威胁着人类健康。并且多药耐药细菌的出现增加了患者的发病率和死亡率，因此有必要开发创新或替代疗法。在此，建立了具有广谱细菌识别能力的光活化纳米治疗剂，作为抗病原体的无抗生素治疗剂。外部基于苯基硼酸的糖基聚合物的纳米疗法增加了稳定性和生物相容性，并显示了细菌识别的能力。一旦用近红外光照射，这种具有高光热转化效率的纳米药物就会破坏细胞质膜，从而杀死细菌细胞。重要的是，它还消除了由两种耐药革兰氏阴性细菌形成的生物膜（铜绿假单胞菌和革兰氏阳性菌（金黄色葡萄球菌）有效。因此，这种具有低毒性的无抗生素纳米疗法为对抗日益严重的抗菌药物耐药性提供了一种有前途的方法。

更新日期：2021-01-18

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