In recent years, the use of poly(amidoamine) (PAMAM) dendrimers of different generations as building blocks or reactive modules to construct core–shell tecto dendrimers (CSTDs) that are superior to the performance of single-generation dendrimers has received great attention in the field of biomedical applications. The CSTDs are always based on high-generation dendrimers as the core and low-generation dendrimers as the shell; not only do they have excellent properties similar to single high-generation dendrimers, but they also have overcome some of the shortcomings (e.g., limited drug loading capacity or enhanced permeability and retention effect due to small size) of single-generation dendrimers in biomedical applications. Herein, the recent advances of CSTDs synthesized by different approaches as nanoplatforms for different biomedical applications, particularly for chemotherapy, gene delivery, and combination therapy, as well as biological imaging, are summarized. In addition, the current challenges and future perspectives of CSTDs are also discussed.

中文翻译：

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用于生物医学应用的核壳 Tecto 树枝状聚合物的合成和成型

近年来，使用不同代的聚（酰胺胺）（PAMAM）树枝状大分子作为构建块或反应模块来构建性能优于单代树枝状大分子的核壳结构树枝状大分子（CSTD）在生物医学应用领域。CSTD始终以高代树枝状大分子为核心，低代树枝状大分子为外壳；它们不仅具有类似于单一高代树枝状大分子的优异性能，而且还克服了单代树枝状大分子在生物医学应用中的一些缺点（例如载药量有限或由于体积小而导致渗透性和保留效果增强） . 在此处，总结了通过不同方法合成的 CSTD 作为纳米平台用于不同生物医学应用的最新进展，特别是用于化学疗法、基因传递和联合治疗以及生物成像。此外，还讨论了 CSTD 当前面临的挑战和未来前景。