Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

中文翻译：

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从Persea americana（鳄梨）油中分离出的脂肪酸衍生物可防止新霉素诱导的毛细胞损伤

鳄梨油对人体健康有益，并且据报道对感觉神经性听力损失（SNHL）具有有益作用。但是，尚未发现鳄梨油中影响SNHL的化合物。在这项研究中，我们使用广泛的光谱分析方法从鳄梨油中鉴定出20种化合物，包括两种新的和18种已知的脂肪酸衍生物。在耳毒性斑马鱼模型中研究了分离出的化合物改善SNHL的功效。这两个新化合物分别是（2 R，4 R，6 Z）-1,2,4-三羟基壬二烯-6-烯和（2 R，4 R）-1,2,4-三羟基庚二烯-14,16-烯（化合物1和2）以及化合物7、9、14、17和19在有毒斑马鱼的受损毛细胞中显示出显着改善。这些结果得出结论，鳄梨油中的化合物以及油本身对耳毒性斑马鱼的受损耳毛细胞具有再生作用。