This paper presents for the first time a successful fabrication of ternary ZnO/TiO₂/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO₂) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO₂ and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO₂/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO₂/Ag, Ag and TiO₂ alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO₂/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO₂. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells.

中文翻译：

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三元ZnO / TiO2 / Ag纳米复合材料的简便原位制备，具有增强的杀菌和生物相容性

本文首次成功地制备了由巴戟天果实（MCF）提取物合成的三元ZnO / TiO ₂ / Ag纳米复合材料，该复合材料由氧化锌（ZnO），二氧化钛（TiO ₂）和银（Ag）纳米颗粒（NP）组成。。采用共沉淀法合成ZnONPs，并在微波辐射下将TiO ₂和Ag引入前驱体溶液中，得到ZnO / TiO ₂ / Ag纳米复合材料。与单独的二元TiO ₂ / Ag，Ag和TiO ₂相比，该材料对细菌病原体表现出增强的杀菌作用。合成后的ZnO / TiO _2的体外细胞毒性结果RAW 264.7巨噬细胞和A549细胞系上的/ AgNCs在细胞毒性中显示出负作用，但与单独的Ag和二元Ag / TiO ₂相比，对抗菌剂的贡献惊人。这项研究表明，所得的三元金属/双半导体纳米复合材料可为根除细菌性病原体提供治疗策略，而不会影响健康的哺乳动物细胞。