The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) signals. However, their association with the balance between neuronal excitation and inhibition (E/I-B), which is closely related to the activities of glutamate and γ-aminobutyric acid (GABA) and the receptor availability (RA) of GABA_A and mGluR5, remains unexplored. This research investigates these associations during the resting state (RS) condition using simultaneously recorded PET/MR/EEG (trimodal) data. The trimodal data were acquired from three studies using different radio-tracers such as, [¹¹C]ABP688 (ABP) (N = 9), [¹¹C]Flumazenil (FMZ) (N = 10) and 2-[¹⁸F]fluoro-2-deoxy-d-glucose (FDG) (N = 10) targeted to study the mGluR5, GABA_A receptors and glucose metabolism respectively. Glucose metabolism and neuroreceptor binding availability (non-displaceable binding potential (BP_ND)) of GABA_A and mGluR5 were found to be significantly higher and closely linked within core resting-state networks (RSNs). The neuronal generators of EEG microstates and the fMRI measures were most tightly associated with the BP_ND of GABA_A relative to mGluR5 BP_ND and the glucose metabolism, emphasising a predominance of inhibitory processes within in the core RSNs at rest. Changes in the neuroreceptors leading to an altered coupling with glucose metabolism may render the RSNs vulnerable to psychiatric conditions. The paradigm employed here will likely help identify the precise neurobiological mechanisms behind these alterations in fMRI functional connectivity and EEG oscillations, potentially benefitting individualised healthcare treatment measures.

神经元活动和葡萄糖能量代谢的共生反映在功能磁共振成像（fMRI）和脑电图（EEG）信号的生成中。然而，它们与神经元兴奋和抑制（E/IB）之间的平衡（E/IB）之间的关系仍有待探索，而神经元兴奋和抑制之间的平衡与谷氨酸和γ-氨基丁酸（GABA）的活性以及GABA _A和mGluR5的受体可用性（RA）密切相关。 。本研究使用同时记录的 PET/MR/EEG（三模态）数据研究静息状态 (RS) 条件下的这些关联。三峰数据是从使用不同放射性示踪剂的三项研究中获得的，例如[ ¹¹ C]ABP688 (ABP) ( N  = 9)、[ ¹¹ C]氟马西尼 (FMZ) ( N  = 10) 和 2-[ ¹⁸ F]氟-2-脱氧-d-葡萄糖 (FDG) ( N  = 10) 分别靶向研究 mGluR5、GABA _A受体和葡萄糖代谢。发现GABA _A和 mGluR5 的葡萄糖代谢和神经受体结合可用性（不可置换结合电位 (BP _ND )）显着较高，并且在核心静息态网络 (RSN) 内紧密相连。EEG 微状态和功能磁共振成像测量的神经元发生器与GABA _{A的 BP ND}相对于 mGluR5 BP _ND和葡萄糖代谢最为密切相关，强调了静止时核心 RSN 内抑制过程的主导地位。神经感受器的变化导致与葡萄糖代谢的耦合改变，可能使 RSN 容易受到精神疾病的影响。这里采用的范式可能有助于确定功能磁共振成像功能连接和脑电图振荡这些变化背后的精确神经生物学机制，从而可能有利于个性化的医疗保健治疗措施。