Abstract

From the EtOAc-soluble extract of the stems of Buchanania lucida, one new lignan, (+)-(8S,8′S)-5′-methoxy-4,4′-di-O-methylsecoisolariciresinol (1), together with five known compounds (2–6) were isolated. Their structures were elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of 1 was determined based on the Cotton effects in the ECD spectrum. In the tyrosinase inhibitory activity test, p-hydroxybenzoic acid (6) showed the strong effect, with an IC₅₀ value of 9.35 µM.

中文翻译：

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一种新的木脂素来自 Buchanania lucida Blume (Anacardiaceae) 的茎

摘要

从Buchanania lucida茎的 EtOAc 可溶性提取物中，一种新的木脂素，(+)-(8 S ,8' S )-5'-methoxy-4,4'-di- O -methylsecoisolariciresinol ( 1 )，一起与五种已知化合物 ( 2-6 ) 分离。它们的结构是在核磁共振光谱解释的基础上阐明的。1的绝对构型是根据 ECD 谱中的棉花效应确定的。在酪氨酸酶抑制活性试验中，对羟基苯甲酸( 6 )显示出强效，IC ₅₀值为9.35 µM。