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A new lignan from the stems of Buchanania lucida Blume (Anacardiaceae)
Natural Product Research ( IF 1.9 ) Pub Date : 2021-01-18 , DOI: 10.1080/14786419.2020.1871341
Nhan Trung Nguyen 1, 2, 3 , Phu Hoang Dang 1, 2 , Hai Xuan Nguyen 1, 2 , Tho Huu Le 1, 2 , Truong Nhat Van Do 1, 2 , Mai Thanh Thi Nguyen 1, 2, 3
Affiliation  

Abstract

From the EtOAc-soluble extract of the stems of Buchanania lucida, one new lignan, (+)-(8S,8′S)-5′-methoxy-4,4′-di-O-methylsecoisolariciresinol (1), together with five known compounds (2–6) were isolated. Their structures were elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of 1 was determined based on the Cotton effects in the ECD spectrum. In the tyrosinase inhibitory activity test, p-hydroxybenzoic acid (6) showed the strong effect, with an IC50 value of 9.35 µM.



中文翻译:

一种新的木脂素来自 Buchanania lucida Blume (Anacardiaceae) 的茎

摘要

Buchanania lucida茎的 EtOAc 可溶性提取物中,一种新的木脂素,(+)-(8 S ,8' S )-5'-methoxy-4,4'-di- O -methylsecoisolariciresinol ( 1 ),一起与五种已知化合物 ( 2-6 ) 分离。它们的结构是在核磁共振光谱解释的基础上阐明的。1的绝对构型是根据 ECD 谱中的棉花效应确定的。在酪氨酸酶抑制活性试验中,羟基苯甲酸( 6 )显示出强效,IC 50值为9.35 µM。

更新日期:2021-01-18
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