Abstract

One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α-glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC₅₀ values of 2.82 and 13.06 μmol/L, respectively (positive control acarbose, IC₅₀ 385 μmol/L).

中文翻译：

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虎杖中的生物活性酰胺

摘要

从虎杖的根茎中分离出一对新的酰胺对映体（1a和1b）和两种已知的酰胺。使用UV，IR，HRESIMS和NMR数据确定其结构。值得注意的是，化合物1在阿魏酸和白藜芦醇之间具有独特的CC连接。它们的绝对构型通过ECD方法确定。评价所有化合物的α-葡糖苷酶抑制活性，化合物2和3显示出显着的抑制活性，IC ₅₀值分别为2.82和13.06μmol/ L（阳性对照阿卡波糖，IC ₅₀ 385μmol/ L）。