Enantioselective fate of famoxadone during processing of apple cider and grape wine,Chirality

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Enantioselective fate of famoxadone during processing of apple cider and grape wine
Chirality ( IF 2.8 ) Pub Date : 2021-01-18 , DOI: 10.1002/chir.23296
Guofeng Xu ₁ , Xiaohui Jia ₁ , Jing Li ₁ , Lixue Kuang ₁ , Haifei Li ₁ , Fengshou Dong ₂

Affiliation

Famoxadone enantiomers were separated on Lux Amylose‐1 chiral column and determined by ultra‐performance liquid chromatography coupled with tandem mass spectrometry (UPLC‐MS/MS). The half‐lives of R‐(−)‐famoxadone and S‐(+)‐famoxadone were 69.3 and 86.6 h in apple cider, 231.0 and 346.5 h in apple pomace, 69.3 and 77.0 h in grape wine, and 231.0 and 346.5 h in grape pomace, respectively. The enantiomeric fraction (EF) values decreased gradually from 0.498, 0.499, and 0.500 (0 h) to 0.404, 0.374, and 0.427 (144 h) and then increased gradually to 0.474, 0.427, and 0.422 (312 h) in apple cider, grape wine, and grape pomace. The EF value in apple pomace decreased gradually from 0.499 (0 h) to 0.450 (168 h) and then increased gradually to 0.482 (312 h). The processing factors (PFs) for famoxadone ranged from 0.014 to 0.024 in the overall process. The residue of famoxadone reduced 94.7–97.4% after the fermentation process.

中文翻译：

苹果酒和葡萄酒加工过程中法莫沙酮的对映选择性

法莫沙酮对映体在勒克斯直链淀粉-1手性色谱柱上分离，并通过超高效液相色谱-串联质谱法（UPLC-MS / MS）进行测定。R-（-）-法莫沙酮和S-（+）-法莫沙酮的半衰期在苹果酒中为69.3和86.6小时，在苹果渣中为231.0和346.5小时，在葡萄酒中为69.3和77.0小时，以及231.0和346.5小时在葡萄渣中。苹果酒中的对映体分数（EF）值从0.498、0.499和0.500（0 h）逐渐降低到0.404、0.374和0.427（144 h），然后逐渐增加到0.474、0.427和0.422（312 h），葡萄酒和葡萄渣。苹果渣中的EF值从0.499（0 h）逐渐降低至0.450（168 h），然后逐渐升高至0.482（312 h）。在整个过程中，法莫沙酮的加工因子（PFs）为0.014至0.024。

更新日期：2021-02-10

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