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Exosomes from adipose‐derived stem cells and application to skin wound healing
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-01-17 , DOI: 10.1111/cpr.12993 Yang An 1 , Shuyan Lin 2 , Xiaojie Tan 1 , Shiou Zhu 3 , Fangfei Nie 1 , Yonghuan Zhen 1 , Luosha Gu 1 , Chunlei Zhang 4 , Baicheng Wang 1 , Wei Wei 5 , Dong Li 1 , Junhao Wu 2
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-01-17 , DOI: 10.1111/cpr.12993 Yang An 1 , Shuyan Lin 2 , Xiaojie Tan 1 , Shiou Zhu 3 , Fangfei Nie 1 , Yonghuan Zhen 1 , Luosha Gu 1 , Chunlei Zhang 4 , Baicheng Wang 1 , Wei Wei 5 , Dong Li 1 , Junhao Wu 2
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Skin wound healing is an intractable problem that represents an urgent clinical need. To solve this problem, a large number of studies have focused on the use of exosomes (EXOs) derived from adipose-derived stem cells (ADSCs). This review describes the mechanisms whereby ADSCs-EXOs regulate wound healing and their clinical application. In the wound, ADSCs-EXOs modulate immune responses and inflammation. They also promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling which inhibits scar hyperplasia. Compared with ADSCs therapeutics, ADSCs-EXOs have highly stability and are easily stored. Additionally, they are not rejected by the immune system and have a homing effect and their dosage can be easily controlled. ADSCs-EXOs can improve fat grafting and promote wound healing in patients with diabetes mellitus. They can also act as a carrier and combined scaffold for treatment, leading to scarless cutaneous repair. Overall, ADSCs-EXOs have the potential to be used in the clinic to promote wound healing.
中文翻译：
来自脂肪干细胞的外泌体及其在皮肤伤口愈合中的应用
皮肤伤口愈合是一个棘手的问题，代表了迫切的临床需求。为了解决这个问题，大量的研究集中在使用来源于脂肪干细胞（ADSCs）的外泌体（EXOs）。本综述描述了 ADSCs-EXO 调节伤口愈合的机制及其临床应用。在伤口中，ADSCs-EXOs 调节免疫反应和炎症。它们还促进血管生成，加速皮肤细胞的增殖和再上皮化，并调节抑制疤痕增生的胶原重塑。与 ADSCs 治疗剂相比，ADSCs-EXOs 具有高度稳定性且易于储存。此外，它们不会被免疫系统排斥并具有归巢效应，并且它们的剂量很容易控制。ADSCs-EXOs可以改善糖尿病患者的脂肪移植并促进伤口愈合。它们还可以作为载体和组合支架进行治疗，从而实现无疤痕皮肤修复。总体而言，ADSCs-EXOs 有潜力用于临床以促进伤口愈合。
更新日期：2021-01-17
中文翻译：
来自脂肪干细胞的外泌体及其在皮肤伤口愈合中的应用
皮肤伤口愈合是一个棘手的问题，代表了迫切的临床需求。为了解决这个问题，大量的研究集中在使用来源于脂肪干细胞（ADSCs）的外泌体（EXOs）。本综述描述了 ADSCs-EXO 调节伤口愈合的机制及其临床应用。在伤口中，ADSCs-EXOs 调节免疫反应和炎症。它们还促进血管生成，加速皮肤细胞的增殖和再上皮化，并调节抑制疤痕增生的胶原重塑。与 ADSCs 治疗剂相比，ADSCs-EXOs 具有高度稳定性且易于储存。此外，它们不会被免疫系统排斥并具有归巢效应，并且它们的剂量很容易控制。ADSCs-EXOs可以改善糖尿病患者的脂肪移植并促进伤口愈合。它们还可以作为载体和组合支架进行治疗，从而实现无疤痕皮肤修复。总体而言，ADSCs-EXOs 有潜力用于临床以促进伤口愈合。
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